Table 2

HRs for mortality risk over 18 years associated with baseline type 2 diabetes status and comorbid symptoms of anxiety and depression by sex (HUNT2 Study, 1995–2013)

All (N = 64,177)Women (n = 34,116)Men (n = 30,061)
Unadjusted HR*95% CIAdjusted HR95% CIAdjusted HR95% CIAdjusted HR95% CI
T2D and DEP
 No T2D, low DEP(ref)(ref)(ref)(ref)
 No T2D, high DEP1.371.26, 1.501.271.14, 1.411.261.08, 1.461.261.08, 1.47
 T2D, low DEP1.551.41, 1.711.501.32, 1.701.861.53, 2.261.311.10, 1.55
 T2D, high DEP2.762.00, 3.842.101.41, 3.131.951.22, 2.723.471.96, 6.14
T2D and ANX
 No T2D, low ANX(ref)(ref)(ref)(ref)
 No T2D, high ANX1.301.21, 1.381.201.11, 1.301.211.08, 1.341.201.06, 1.34
 T2D, low ANX1.521.37, 1.691.441.26, 1.651.821.48, 2.251.261.06, 1.51
 T2D, high ANX1.991.57, 2.531.661.25, 2.191.380.95, 2.012.141.41, 3.27
T2D and comorbid DEP-ANX
 No T2D, low DEP-ANX(ref)(ref)(ref)(ref)
 No T2D, high DEP-ANX1.371.23, 1.561.221.07, 1.401.151.05, 1.391.271.04, 1.53
 T2D, low DEP-ANX1.561.45, 1.691.441.29, 1.601.651.40, 1.951.301.12, 1.51
 T2D, high DEP-ANX2.561.73, 3.792.011.18, 3.001.140.57, 2.293.421.84, 6.38
  • ANX, anxious symptoms; DEP, depressive symptoms; DEP-ANX, comorbid depressive and anxious symptoms; T2D, type 2 diabetes.

  • *Adjusted for age and sex.

  • †Adjusted for age, sex, education, waist circumference, physical activity, smoking, antidepressant use, insulin use, family history of diabetes, and comorbid chronic conditions.