Table 1

Biomarker panels for the diagnosis of advanced fibrosis (stages 3 and 4)

Parameters includednPPVNPVPatients unable to be classified (“gray zone”)
FibroTest (115)Age, sex26760%98%32%
Total bilirubin
GGT α2-macroglobulin
Apolipoprotein A1
Haptoglobin
NAFLD fibrosis score (116)Age, BMI73382%88%24%
Diabetes
AST/ALT ratio
Platelet, albumin
BARD score (117)BMI82743%96%N/A
Diabetes
AST/ALT ratio
FIB-4 index (118)Age54180%90%30%
AST and ALT
Platelet
NAFIC score (119)Ferritin61936%99%15%
Type IV collagen
Insulin
Hepascore (120)Age, sex24257%92%11%
Total bilirubin GGT α2-macroglobulin
Hyaluronic acid
  • N/A, not applicable; NPV, negative predictive value; PPV, positive predictive value.

  • †No independent validation cohort included in the study.