Table 1

Clinical characteristics of the study group stratified by the rate of the renal function decline

Renal Function Decline
CharacteristicMinimal(n = 53)Moderate(n = 53)Fast(n = 52)P value
At baseline
 Male [n (%)]25 (47)28 (53)29 (46)0.38
 Age (years)45 ± 1042 ± 840 ± 100.003
 Duration of diabetes (years)30 ± 829 ± 827 ± 90.007
 HbA1c (%)8.5 ± 1.39.3 ± 1.69.6 ± 1.70.005
 HbA1c (mmol/mol)69 ± 1478 ± 1881 ± 190.005
 Serum cholesterol (mg/dL)191 ± 43219 ± 63219 ± 710.03
 Systolic blood pressure (mmHg)134 ± 20136 ± 19137 ± 240.57
 Diastolic blood pressure (mmHg)75 ± 1179 ± 1180 ± 110.07
 Antihypertensive/renoprotective treatment (%)9392800.07
 ACR (μg/g creatinine)670 (403, 1,009)1,007 (680, 1,934)1,533 (748, 3,526)0.0004
 eGFR (mL/min/1.73 m2)50 ± 1248 ± 1344 ± 130.02
Follow-up
 Length (years)14.4 (9.7, 18.4)11.8 (7.7, 13.8)9.2 (5.6, 12.1)<0.001
 Annual eGFR slope (mL/min/1.73 m2)−1.9 (−1.0 to −2.5)−5.0 (−3.9 to −5.9)−10.9 (−8.5 to −15.6)By design
 Incidence of ESRD
  Cases (n)163548<0.001
  Rate per 1,000 person-years*1.1 (0.6, 1.9)3.7 (2.6, 5.1)10.5 (7.7, 13.9)<0.001
  • Data are mean ± SD or median (25th, 75th percentile) unless otherwise indicated.

  • *Incidence rate of ESRD is accompanied by 95% CI.