Table 3

Multivariate linear regression of LV circumferential strain and ejection fraction in relation to cardiovascular risk factors

Ecc (%)Ejection fraction (%)
Covariateβ ± SEP valueβ ± SEP value
Age (per 10 years of age)0.30 ± 0.130.02360.80 ± 0.350.0226
Sex (female vs. male)−0.44 ± 0.200.03181.77 ± 0.540.0012
Cohort (primary vs. secondary intervention)−0.15 ± 0.170.39260.34 ± 0.460.4592
Smoking (yes vs. no)0.64 ± 0.270.0188−0.16 ± 0.720.8184
BMI (kg/m2)0.04 ± 0.020.03670.05 ± 0.050.3832
Mean diastolic BP (mmHg)0.07 ± 0.020.00020.02 ± 0.050.7521
Mean HDL cholesterol (mg/dL)−0.02 ± 0.0080.02360.02 ± 0.020.2383
Mean HbA1c during the DCCT/EDIC study0.28 ± 0.100.0043−0.20 ± 0.260.4343
Myocardial scar
 Nonischemic vs. none1.13 ± 0.580.0518−8.93 ± 1.54<0.0001
 Ischemic vs. none−0.04 ± 0.580.9506−3.67 ± 1.530.0164
  • Only the most significant lipid variable (i.e., HDL cholesterol) was included in the final model. The model was also adjusted for CMR machine type. Positive regression coefficients indicate a decrease in function because Ecc has a negative value. Boldface values indicate significance or clear trend at P ≤ 0.05.