Table 2

HR estimates of CHD and ischemic stroke associated with TG and HDL-C status in the SHS

CHDIschemic stroke
NoncaseCaseBasic model1Full model2NoncaseCaseBasic model1Full model2
TG3
 Normal TG1,695 (79)459 (21)ReferenceReference2,063 (96)91 (4)ReferenceReference
 High TG734 (69)330 (31)1.57 (1.36–1.81)1.19 (1.00–1.42)997 (94)67 (6)1.64 (1.19–2.25)1.28 (0.84–1.94)
HDL-C3
 Normal HDL-C1,154 (79)313 (21)ReferenceReference1,410 (96)57 (4)ReferenceReference
 Low HDL-C1,275 (73)476 (27)1.44 (1.24–1.67)1.17 (0.99–1.39)1,649 (94)102 (6)1.69 (1.22–2.34)1.35 (0.89–2.06)
TG-HDL status
 Normal TG-HDL940 (80)238 (20)ReferenceReference1,131 (96)47 (4)ReferenceReference
 Normal TG, low HDL754 (77)221 (23)1.27 (1.05–1.53)1.08 (0.87–1.33)931 (95)44 (5)1.26 (0.83–1.91)0.99 (0.62–1.58)
 High TG, normal HDL213 (74)75 (26)1.39 (1.06–1.81)1.04 (0.76–1.41)279 (97)9 (3)0.85 (0.42–1.74)0.57 (0.24–1.38)
 High TG, low HDL520 (67)255 (33)1.89 (1.58–2.27)1.32 (1.06–1.64)717 (93)58 (7)2.20 (1.50–3.25)1.46 (0.92–2.33)
  • Data are reported as n (%) or HR (95% CI).

  • 1Basic models stratified on SHS centers and included age and sex.

  • 2Full models additionally included BMI, smoking (current, past, ever), estimated LDL-C level, diabetes (yes/no), antihypertensive medications (yes/no), categorical physical activity (MET-h/week in quartile), UACR (continuous), and eGFR-MDRD (continuous).

  • 3High TG: fasting TG ≥150 mg/dL; low HDL-C: HDL-C <40 mg/dL (men) or <50 mg/dL (women).