Table 3

TG-HDL status in relation with CHD or ischemic stroke in participants without and with diabetes

No diabetesDiabetes
Noncase, n (%)Case, n (%)Full model1Noncase, n (%)Case, n (%)Full model1
HR (95% CI)HR (95% CI)
CHD (P interaction = 0.003)
 TG (per SD increase)21.07(0.92–1.24)1.47(1.08–2.00)
 HDL-C (per SD increase)30.87(0.75–1.01)0.95(0.83–1.08)
 TG-HDL status
  Normal TG-HDL681 (85)122 (15)1 (reference)233 (69)103 (30)1 (reference)
  Normal TG, low HDL435 (81)103 (19)1.26(0.94–1.69)306 (73)111 (27)0.92(0.67–1.26)
  High TG, normal HDL138 (82)30 (18)1.14(0.74–1.76)71 (62)43 (38)0.99(0.64–1.54)
  High TG, low HDL251 (83)50 (17)0.88(0.60–1.29)258 (57)192 (43)1.54(1.15–2.06)
Ischemic stroke (P interaction = 0.060)
 TG (per SD increase)21.15(0.82–1.62)1.43(0.74–2.73)
 HDL-C (per SD increase)30.93(0.69–1.26)0.72(0.53–0.97)
 TG-HDL status
  Normal TG-HDL773 (96)34 (4)1 (reference)326 (96)13 (4)1 (reference)
  Normal TG, low HDL526 (98)13 (2)0.53(0.23–1.19)391 (93)31 (7)1.82(0.91–3.66)
  High TG, normal HDL164 (98)4 (2)0.53(0.15–1.81)112 (97)4 (3)0.77(0.21–2.83)
  High TG, low HDL287 (94)17 (6)1.16(0.55–2.45)417 (91)40 (9)2.13(1.06–4.29)
  • High TG, fasting TG ≥150 mg/dL; low HDL-C, HDL-C <40 mg/dL (men) or <50 mg/dL (women).

  • 1Full model stratified on SHS center and included age, sex, BMI, smoking (current, past, ever), estimated LDL-C level, antihypertensive medications (yes/no), categorical physical activity (MET-h/week in quartile), UACR (continuous), and eGFR (continuous).

  • 2Per SD change in TG: 80 mg/dL in participants with no diabetes, 207 mg/dL participants with diabetes.

  • 3Per SD change in HDL-C: 15 mg/dL in participants with no diabetes, 12 mg/dL in participants with diabetes.