Outcome at 3 years^{*} | Significant predictors | β | t | P |
---|---|---|---|---|

A. ISSI-2 | ISSI-2 at 1 year | 0.552669 | 8.36 | <0.0001 |

BMI at 1 year | −16.72522 | −3.32 | 0.001 | |

B. IGI/HOMA-IR | IGI/HOMA-IR at 1 year | 0.007735 | 2.88 | 0.004 |

BMI at 1 year | −0.028240 | −1.98 | 0.049 | |

C. Matsuda index | Matsuda index at 1 year | 0.022948 | 4.85 | <0.0001 |

BMI at 1 year | −0.048227 | −7.28 | <0.0001 | |

Change in BMI from 1 to 3 years | −0.100288 | −5.79 | <0.0001 | |

Asian ethnicity | −0.289391 | −3.37 | 0.0009 | |

Nonwhite non-Asian ethnicity | −0.325275 | −4.12 | <0.0001 | |

Family history of diabetes | −0.134457 | −2.56 | 0.01 | |

Adiponectin at 1 year | 0.033599 | 4.09 | <0.0001 | |

PAI-1 at 1 year | −0.000117 | −2.59 | 0.01 | |

Change in PAI-1 from 1 to 3 years | −0.000138 | −2.87 | 0.005 | |

D. HOMA-IR | HOMA-IR at 1 year | 0.209465 | 5.41 | <0.0001 |

BMI at 1 year | 0.046018 | 6.22 | <0.0001 | |

Change in BMI from 1 to 3 years | 0.095050 | 5.15 | <0.0001 | |

Nonwhite non-Asian ethnicity | 0.192813 | 2.30 | 0.02 | |

Family history of diabetes | 0.115751 | 2.07 | 0.04 | |

Adiponectin at 1 year | −0.034484 | −4.01 | <0.0001 | |

PAI-1 at 1 year | 0.000100 | 2.08 | 0.04 | |

Change in PAI-1 from 1 to 3 years | 0.000112 | 2.20 | 0.03 | |

CRP at 1 year | −0.024985 | −2.56 | 0.01 | |

Change in CRP from 1 to 3 years | −0.019536 | −2.52 | 0.01 | |

E. Fasting glucose | Fasting glucose at 1 year | 0.617208 | 10.99 | <0.0001 |

BMI at 1 year | 0.029007 | 4.43 | <0.0001 | |

Change in BMI from 1 to 3 years | 0.070800 | 4.1 | <0.0001 | |

CRP at 1 year | −0.025304 | −2.77 | 0.006 | |

Change in CRP from 1 to 3 years | −0.020363 | −2.79 | 0.006 | |

F. 2-h glucose | 2-h glucose at 1 year | 0.640894 | 11.45 | <0.0001 |

BMI at 1 year | 0.062188 | 2.61 | 0.01 | |

Change in BMI from 1 to 3 years | 0.152248 | 2.43 | 0.02 |

↵* Each of these six multiple linear regression models included the covariates age, ethnicity, family history of diabetes, duration of breastfeeding, BMI at 1 year, change in BMI from 1 to 3 years, the measure of the respective outcome variable at 1 year, and both the 1-year measure and change from 1 to 3 years for all of the following: adiponectin, chemerin, RBP-4, CRP, and PAI-1. IGI, insulinogenic index; ISSI-2, Insulin Secretion-Sensitivity Index-2.