Table 1

Trends in hypoglycemia hospitalization by diabetes type

Trend 1Trend 2Trend 3
PeriodAPC (95% CI)PPeriodAPC (95% CI)PPeriodAPC (95% CI)P
Adults with T1DM
 Overall1998–20133.74 (1.70 to 5.83)0.001
 Age-group
  18–44 years1998–20133.91 (0.42 to 7.52)0.03
  45–64 years1998–20135.12 (1.65 to 8.70)0.01
  65–79 years1998–20133.48 (0.59 to 6.46)0.02
   ≥80 years1998–20136.71 (3.52 to 9.99)0.0004
 Sex
  Male1998–20133.36 (1.41 to 5.34)0.002
  Female1998–20134.13 (1.43 to 6.89)0.005
 Diabetes duration
  0–4 years1998–20132.67 (−0.77 to 6.22)0.12
  5–9 years1998–20130.47 (−3.38 to 4.47)0.80
  10–14 years1998–2013−0.14 (−2.97 to 2.76)0.92
   ≥15 years1998–20134.97 (2.66 to 7.33)0.0004
Young and middle-aged adults with T2DM
 Overall1998–20134.12 (0.61 to 7.75)0.02
 Age-group
  18–44 years1998–20134.23 (−0.99 to 9.73)0.11
  45–64 years1998–20133.90 (0.18 to 7.76)0.04
 Sex
  Male1998–20134.04 (0.04 to 8.21)0.048
  Female1998–20133.77 (−1.01 to 8.77)0.11
 Diabetes duration
  <10 years1998–20133.53 (−0.98 to 8.25)0.12
   ≥10 years1998–20131.82 (−2.22 to 6.04)0.36
 Current status of glucose-lowering drug use
  Insulin with/without NIGLD1998–20135.76 (1.11 to 10.64)0.02
  Sulfonylureas with/without NIGLD1998–20131.42 (−2.87 to 5.90)0.50
  Other*1998–20132.93 (−2.08 to 8.20)0.23
Elderly adults with T2DM
 Overall1998–20098.59 (5.76 to 11.50)<0.00012009–2013−8.05 (−14.48 to −1.13)0.03
 Age-group
  65–79 years1998–20098.28 (4.96 to 11.71)0.00022009–2013−8.13 (−16.11 to 0.61)0.06
   ≥80 years1998–20088.86 (4.02 to 13.93)0.0022008–2013−6.41 (−12.45 to 0.06)0.052
 Sex
  Male1998–20099.00 (5.33 to 12.79)0.00022009–2013−6.13 (−14.30 to 2.83)0.15
  Female1998–20098.18 (4.41 to 12.08)0.00052009–2013−9.92 (−18.50 to −0.43)0.04
 Diabetes duration
  0–4 years1998–2013−1.38 (−4.87 to 2.23)0.42
  5–9 years1998–200224.29 (−5.62 to 63.67)0.112002–2013−6.51 (−9.54 to −3.38)0.0009
  10–14 years1998–20053.12 (−3.19 to 9.85)0.292005–200817.90 (−9.17 to 53.03)0.182008–2013−12.95 (−17.16 to −8.52)0.0002
   ≥15 years1998–200816.60 (8.21 to 25.64)0.00092008–2013−6.32 (−13.67 to 1.66)0.11
 Current status of glucose-lowering drug use
  Sulfonylureas only1998–20139.42 (5.11 to 13.91)0.0003
  Sulfonylureas + other NIGLD1998–20133.74 (0.86 to 6.71)0.01
  Insulin only1998–20137.62 (4.34 to 11.01)0.0002
  Insulin + NIGLD1998–20099.50 (3.98 to 15.30)0.0032009–2013−8.71 (−19.92 to 4.06)0.15
  Other*1998–2013−0.39 (−5.29 to 4.77)0.87
  • APC, annual percent change.

  • *Included self-management alone (i.e., not currently taking any glucose-lowering drug), NIGLD monotherapy (excluding sulfonylureas), or combinations of any glucose-lowering drugs (excluding insulin and sulfonylureas).