Table 3

Risk of hypoglycemic event among patients who experienced an AKI episode during a hospitalization vs. those who did not experience an AKI episode within 90 days postdischarge, by CKD status and preadmission HBA1c subgroups

Subgroup analysesNon-AKIAKI
Mean preadmission outpatient eGFR <60 mL/min/1.73 m2
 PS-matched inadjusted Cox PHRef.1.22 (1.14–1.29)
 PS-matched adjusted Cox PHRef.1.22 (1.15–1.30)
Mean preadmission outpatient eGFR ≥60 mL/min/1.73 m2
 PS-matched unadjusted Cox PHRef.1.30 (1.22–1.38)
 PS-matched adjusted Cox PHRef.1.32 (1.24–1.41)
Baseline HbA1c <7%
 PS-matched unadjusted Cox PHRef.1.23 (1.13–1.34)
 PS-matched adjusted Cox PHRef.1.24 (1.14–1.35)
Baseline HbA1c 7–9%
 PS-matched unadjusted Cox PHRef.1.23 (1.13–1.33)
 PS-matched adjusted Cox PHRef.1.24 (1.14–1.34)
Baseline HbA1c >9%
 PS-matched unadjusted Cox PHRef.1.20 (1.06–1.36)
 PS-matched adjusted Cox PHRef.1.27 (1.13–1.44)
Baseline HbA1c missing
 PS-matched unadjusted Cox PHRef.1.34 (1.23–1.45)
 PS-matched adjusted Cox PHRef.1.36 (1.25–1.47)
  • Hypoglycemia was defined as hospital admission, an emergency department visit for hypoglycemia, or an outpatient blood glucose value of <60 mg/dL. PS-matched unadjusted Cox PH analysis controlled for confounding via matching only; PS-matched adjusted Cox PH analysis additionally controlled for confounding via direct covariate adjustment.