Table 1

Characteristics of the FoCus subset study cohort

BMI <20 kg/m2 (n = 66)BMI 20–25 kg/m2 (n = 149)BMI >30 kg/m2PtotalP1P2P3P4P5P6
Without T2D (n = 148)With T2D (n = 148)
Age (years)45.53 ± 15.5852.90 ± 10.8252.82 ± 10.8652.93 ± 10.83<0.001<0.001<0.001<0.001NSNSNS
Female sex (%)86.467.166.966.2<0.05<0.01<0.01<0.01NSNSNS
Height (m)1.70 (1.64; 1.75)1.72 (1.68; 1.79)1.70 (1.64; 1.78)1.70 (1.64; 1.80)NS
Weight (kg)55.45 (50.38; 58.43)66.80 (61.35; 74.40)111.30 (95.73; 132.20)123.25 (102.50; 148.08)<0.001<0.001<0.001<0.001<0.001<0.001<0.001
BMI (kg/m2)19.09 (18.18; 19.73)22.81 (21.45; 23.98)37.08 (32.40; 45.13)42.80 (36.75; 47.94)<0.001<0.001<0.001<0.001<0.001<0.001<0.001
Blood pressure (mmHg)
 Systolic 120.00 (110.00; 130.00)120.00 (115.00; 130.00)130.00 (130.00; 140.00)140.00 (130.00; 140.00)<0.0010.004<0.001<0.001<0.001<0.001NS
 Diastolic80.00 (70.00; 80.00)80.00 (70.00; 80.00)80.00 (80.00; 90.00)80.00 (80.00; 90.00)<0.0010.005<0.001<0.001<0.001<0.001<0.001
Glucose (mg/dL)88.00 (85.00; 95.25)93.00 (87.00; 99.00)100.00 (91.00; 108.00)123.00 (104.25; 162.00)<0.001NS<0.001<0.001<0.001<0.001<0.001
Insulin (mIU/L)5.25 (3.90; 8.30)6.50 (5.10; 9.28)17.20 (11.00; 24.23)25.50 (15.53; 43.88)<0.001NS<0.001<0.001<0.001<0.001<0.001
HOMA-IR index1.14 (0.83; 1.89)1.49 (1.08; 2.26)4.15 (2.57; 5.71)7.87 (4.18; 16.94)<0.0010.005<0.001<0.001<0.001<0.001<0.001
Triglycerides (mg/dL)68.00 (54.75; 92.50)87.00 (64.00; 112.50)121.50 (91.25; 179.25)166.00 (122.00; 237.75)<0.0010.001<0.001<0.001<0.001<0.001<0.001
Lp(a) (mg/L)117.00 (95.00; 361.00)121.00 (95.00; 320.00)148.00 (95.00; 378.50)108.00 (95.00; 324.25)NS
IL-6 (pg/mL)2.15 (1.50; 3.73)2.50 (1.50; 4.20)4.00 (2.90; 5.35)5.20 (3.33; 7.08)<0.001<0.001<0.001<0.001<0.0010.001
CRP (mg/L)0.90 (0.90; 1.13)0.90 (0.90; 1.90)4.35 (1.75; 8.65)5.85 (2.90; 10.88)<0.001NS<0.001<0.001<0.001<0.001NS
  • Data are presented as mean ± SD, as median (interquartile range), or as otherwise indicated. Ptotal, P value for overall comparison. P1–6 = pairwise comparison: P1, BMI <20 kg/m2 vs. BMI 20–25 kg/m2; P2, BMI <20 kg/m2 vs. BMI >30 kg/m2 without T2D; P3, BMI <20 kg/m2 vs. BMI >30 kg/m2 with T2D; P4, BMI 20–25 kg/m2 vs. BMI >30 kg/m2 without T2D; P5= BMI 20–25 kg/m2 vs. BMI > 30 kg/m2 with T2D; P6, BMI >30 kg/m2 without T2D vs. BMI > 30 kg/m2 with T2D. CRP, C-reactive protein; IR, insulin resistance; Lp(a), lipoprotein(a); IL-6, interleukin-6; T2D, type 2 diabetes.