Table 2

Risk of hypoglycemic events among patients who experienced AKI during hospitalization within 90 days postdischarge

Non-AKIAKI
A) Summary characteristics
  Patients65,15165,151
  Composite hypoglycemic events3,5194,341
  Follow-up time (person-years)14,953.8514,648.28
  Unadjusted rate per 100 person-years (95% CI)23.5 (22.9–24.2)29.6 (28.9–30.4)
B) Primary analyses
  PS-matched unadjusted Cox PH, HR (95% CI)Ref.1.25 (1.20–1.31)
  PS-matched adjusted Cox PH, HR (95% CI)Ref.1.27 (1.22–1.33)
C) Sensitivity analyses
  Outcome defined as a glucose value <50 mg/dL
  Hypoglycemia events of glucose <50 mg/dL1,5171,909
  Follow-up time (person-years)15,253.8215,020.53
  Unadjusted rate per 100 person-years (95% CI)9.95 (9.48–10.43)12.71 (12.19–13.25)
  PS-matched unadjusted Cox PH, HR (95% CI)Ref.1.27 (1.19–1.36)
  PS-matched adjusted Cox PH, HR (95% CI)Ref.1.29 (1.21–1.39)
  • A) Summary of patients, outcomes, and follow-up time for all analyses; B) risk of hypoglycemic event among patients who experienced an AKI episode during a hospitalization vs. those who did not experience an AKI episode within 90 days postdischarge; and C) sensitivity analysis using a more strict definition for the outcome, where hypoglycemia was defined as a glucose blood value <50 mg/dL in the outpatient setting. Composite hypoglycemia event was defined as hospital admission, an emergency department visit for hypoglycemia, or an outpatient blood glucose value of <60 mg/dL. PS-matched unadjusted Cox PH analysis controlled for confounding via matching only; PS-matched adjusted Cox PH analysis additionally controlled for confounding via direct covariate adjustment.

  • Sensitivity analysis was performed using a more strict definition for the outcome, where hypoglycemia was defined as a glucose blood value <50 mg/dL in the outpatient setting.