Table 1

Baseline characteristics according to severe hypoglycemia status among 11,495 participants with a baseline MMSE score ≥24

VariableSevere hypoglycemiaNo severe hypoglycemia
Total n42711,068
Age, years65.5 (8.1)63.2 (7.7)A
Female112 (26.2)3,663 (33.1)B
Education
 <8 years139 (32.6)3,564 (32.2)
 9–12 years146 (34.2)3,047 (27.5)B
 >12 years142 (33.3)4,455 (40.2)B
Ethnicity
 White252 (59.0)6,784 (61.3)
 Black9 (2.1)295 (2.7)
 South Asian9 (2.1)419 (3.8)
 Other Asian26 (6.1)707 (6.4)
 Latin121 (28.3)2,588 (23.4)B
 Other10 (2.3)274 (2.5)
Depression372 (16.9)1,546 (14.0)
Mean BMI29.2 (4.6)29.9 (5.3)B
Previous CVD1279 (65.3)6,548 (59.2)B
Hypertension356 (83.4)8,717 (78.8)B
Hyperlipidemia301 (70.5)7,385 (66.7)
Current smoker53 (12.4)1,410 (12.7)
Alcohol2126 (29.5)2,612 (23.6)B
Previous DM395 (92.5)9,736 (88.0)B
DM duration, years7.5 (7.5)5.3 (5.8)A
Mean A1C, %6.6 (1.0)6.5 (0.9)B
Mean FPG, mmol/L7.5 (2.1)7.3 (2.0)B
Glargine allocation329 (77.0)5,428 (49.0)A
Standard allocation98 (23.0)5,640 (51.0)A
n-3 allocation214 (50.1)5,571 (50.3)
Placebo allocation213 (49.9)5,496 (49.7)
Metformin114 (26.7)3,018 (27.3)
Sulfonylurea155 (36.3)3,141 (28.4)A
Other glucose-lowering drugs20 (4.7)315 (2.8)B
Mean MMSE score28.2 (1.9)28.5 (1.7)A
  • For categorical outcomes, values are presented as n (%). For continuous variables, values are presented as the mean (SD). DM, diabetes mellitus.

  • 1Defined as previous revascularization, myocardial infarction, or stroke. 2More than two drinks consumed in a week. 3Defined as an affirmative answer regarding the question of feeling “sad, low in spirits, or depressed for 2 or more weeks” and during that time also having “thought a lot about death or required treatment for depression.”

  • A P < 0.001.

  • B P ≤ 0.05.