Table 2

Baseline characteristics according to nonsevere hypoglycemia status among 11,495 participants with a baseline MMSE ≥24

VariableNonsevere hypoglycemiaNo nonsevere hypoglycemia
Total n3,2568,239
Age, years62.8 (7.4)63.5 (7.8)A
Female1,013 (31.1)2,762 (33.5)B
Education
 <8 years1,066 (32.7)2,637 (32.0)
 9–12 years914 (28.0)2,279 (27.7)
 >12 years1,276 (39.2)3,321 (40.3)
Ethnicity
 White1,843 (56.6)5,193 (63.0)A
 Black86 (2.6)218 (2.6)
 South Asian112 (3.4)316 (3.8)
 Other Asian183 (5.6)550 (6.7)B
 Latin966 (29.7)1,743 (21.2)A
 Other66 (2.0)218 (2.6)
Depression3547 (16.8)1,071 (13)A
Mean BMI29.6 (5.1)30.0 (5.3)A
Previous CVD11,947 (59.8)4,880 (59.2)
Hypertension2,562 (78.7)6,511 (79.0)
Hyperlipidemia2,198 (67.5)5,488 (66.6)
Current smoker445 (13.7)1,018 (12.4)
Alcohol2810 (24.9)1,928 (23.4)
Previous DM3,049 (93.6)7,082 (86.0)A
DM duration, years6.3 (6.4)4.9 (5.6)A
Mean A1C, %6.7 (1.0)6.4 (0.9)A
Mean FPG, mmol/L7.6 (2.1)7.2 (1.9)B
Glargine allocation2,429 (74.6)3,328 (40.4)A
Standard allocation827 (25.4)4,911 (59.6)A
n-3 allocation1,621 (49.8)4,164 (50.5)
Placebo allocation1,635 (50.2)4,074 (49.4)
Metformin879 (27.0)2,253 (27.3)
Sulfonylurea1,310 (40.2)1,986 (24.1)A
Other glucose-lowering drugs101 (3.1)234 (2.8)
Mean MMSE score28.4 (1.8)28.5 (1.7)B
  • For categorical outcomes, values are n (%). For continuous variables, the mean (SD) is given. DM, diabetes mellitus.

  • 1Defined as previous revascularization, myocardial infarction, or stroke. 2More than two drinks consumed in a week. 3Defined as an affirmative answer regarding the question of feeling “sad, low in spirits, or depressed for 2 or more weeks” and during that time also having “thought a lot about death or required treatment for depression.”

  • A P < 0.001.

  • B P = < 0.05.