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Clinical Therapeutics/New Technology-Oral Agents

  • Clinical Therapeutics/New Technology-Oral Agents
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    The SimpliciT1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2 Adaptive Study of TTP399, a Hepatoselective Glucokinase Activator, for Adjunctive Treatment of Type 1 Diabetes
    Klara R. Klein, Jennifer L.R. Freeman, Imogene Dunn, Chris Dvergsten, M. Sue Kirkman, John B. Buse, Carmen Valcarce, on behalf of the SimpliciT1 research group
    Diabetes Care Feb 2021, dc202684; DOI: 10.2337/dc20-2684
  • Open Access
    Metformin Benefits: Another Example for Alternative Energy Substrate Mechanism?
    Andrea Giaccari, Anna Solini, Simona Frontoni, Stefano Del Prato
    Diabetes Care Mar 2021, 44 (3) 647-654; DOI: 10.2337/dc20-1964
  • Open Access
    DPP-4 Inhibitors and Respiratory Infection: A Systematic Review and Meta-analysis of the Cardiovascular Outcomes Trials
    Guillaume Grenet, Samia Mekhaldi, Sabine Mainbourg, Marine Auffret, Catherine Cornu, Jean-Luc Cracowski, François Gueyffier, Jean-Christophe Lega, Michel Cucherat
    Diabetes Care Mar 2021, 44 (3) e36-e37; DOI: 10.2337/dc20-2018
  • Open Access
    Comment on Herring et al. Metabolic Effects of an SGLT2 Inhibitor (Dapagliflozin) During a Period of Acute Insulin Withdrawal and Development of Ketoacidosis in People With Type 1 Diabetes. Diabetes Care 2020;43:2128–2136
    Geremia B. Bolli, Francesca Porcellati, Paola Lucidi, Carmine G. Fanelli
    Diabetes Care Mar 2021, 44 (3) e59-e60; DOI: 10.2337/dc20-2575
  • Open Access
    Response to Comment on Herring et al. Metabolic Effects of an SGLT2 Inhibitor (Dapagliflozin) During a Period of Acute Insulin Withdrawal and Development of Ketoacidosis in People With Type 1 Diabetes. Diabetes Care 2020;43:2128–2136
    Roselle A. Herring, Fariba Shojaee-Moradie, Robert Garesse, Mary Stevenage, Nicola Jackson, Barbara A. Fielding, Agampodi Mendis, Sigurd Johnsen, A. Margot Umpleby, Melanie Davies, David L. Russell-Jones
    Diabetes Care Mar 2021, 44 (3) e61; DOI: 10.2337/dci20-0072
  • You have access
    Efficacy and Safety of Imeglimin Monotherapy Versus Placebo in Japanese Patients With Type 2 Diabetes (TIMES 1): A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Multicenter Phase 3 Trial
    Julie Dubourg, Pascale Fouqueray, Carole Thang, Jean-Marie Grouin, Kohjiro Ueki
    Diabetes Care Feb 2021, dc200763; DOI: 10.2337/dc20-0763
  • You have access
    Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort
    Neda Rasouli, Naji Younes, Kristina M. Utzschneider, Silvio E. Inzucchi, Ashok Balasubramanyam, Andrea L. Cherrington, Faramarz Ismail-Beigi, Robert M. Cohen, Darin E. Olson, Ralph A. DeFronzo, William H. Herman, John M. Lachin, Steven E. Kahn, the GRADE Research Group
    Diabetes Care Feb 2021, 44 (2) 340-349; DOI: 10.2337/dc20-1787
  • Open Access
    Natriuretic Effect of Two Weeks of Dapagliflozin Treatment in Patients With Type 2 Diabetes and Preserved Kidney Function During Standardized Sodium Intake: Results of the DAPASALT Trial
    Rosalie A. Scholtes, Marcel H.A. Muskiet, Michiel J.B. van Baar, Anne C. Hesp, Peter J. Greasley, Cecilia Karlsson, Ann Hammarstedt, Niki Arya, Daniël H. van Raalte, Hiddo J.L. Heerspink
    Diabetes Care Feb 2021, 44 (2) 440-447; DOI: 10.2337/dc20-2604
  • Open Access
    Dapagliflozin and the Incidence of Type 2 Diabetes in Patients With Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis From DAPA-HF
    Silvio E. Inzucchi, Kieran F. Docherty, Lars Køber, Mikhail N. Kosiborod, Felipe A. Martinez, Piotr Ponikowski, Marc S. Sabatine, Scott D. Solomon, Subodh Verma, Jan Bělohlávek, Michael Böhm, Chern-En Chiang, Rudolf A. de Boer, Mirta Diez, Andre Dukát, Charlotta E.A. Ljungman, Olof Bengtsson, Anna Maria Langkilde, Mikaela Sjöstrand, Pardeep S. Jhund, John J.V. McMurray
    Diabetes Care Feb 2021, 44 (2) 586-594; DOI: 10.2337/dc20-1675
  • You have access
    Effects of Vitamin C Supplementation on Glycemic Control and Cardiovascular Risk Factors in People With Type 2 Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis of Randomized Controlled Trials
    Shaun A. Mason, Michelle A. Keske, Glenn D. Wadley
    Diabetes Care Feb 2021, 44 (2) 618-630; DOI: 10.2337/dc20-1893

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