Genetics-Type 1 Diabetes

Genetics-Type 1 Diabetes

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Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association Study
Meng Zhu, Kuanfeng Xu, Yang Chen, Yong Gu, Mei Zhang, Feihong Luo, Yu Liu, Wei Gu, Ji Hu, Haixia Xu, Zhiguo Xie, Chengjun Sun, Yuxiu Li, Min Sun, Xinyu Xu, Hsiang-Ting Hsu, Heng Chen, Qi Fu, Yun Shi, Jingjing Xu, Li Ji, Jin Liu, Lingling Bian, Jing Zhu, Shuang Chen, Lei Xiao, Xin Li, Hemin Jiang, Min Shen, Qianwen Huang, Chen Fang, Xia Li, Gan Huang, Jingyi Fan, Zhu Jiang, Yue Jiang, Juncheng Dai, Hongxia Ma, Shuai Zheng, Yun Cai, Hao Dai, Xuqin Zheng, Hongwen Zhou, Shining Ni, Guangfu Jin, Jin-Xiong She, Liping Yu, Constantin Polychronakos, Zhibin Hu, Zhiguang Zhou, Jianping Weng, Hongbing Shen, Tao Yang

Diabetes Care Aug 2019, 42 (8) 1414-1421; DOI: 10.2337/dc18-2023
Open Access
Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes
Lue Ping Zhao, George K. Papadopoulos, William W. Kwok, Bryan Xu, Matthew Kong, Antonis K. Moustakas, George P. Bondinas, Annelie Carlsson, Helena Elding-Larsson, Johnny Ludvigsson, Claude Marcus, Martina Persson, Ulf Samuelsson, Ruihan Wang, Chul-Woo Pyo, Wyatt C. Nelson, Daniel E. Geraghty, Åke Lernmark

Diabetes Aug 2019, 68 (8) 1692-1704; DOI: 10.2337/db19-0273
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Trisomy 21 Is a Cause of Permanent Neonatal Diabetes That Is Autoimmune but Not HLA Associated
Matthew B. Johnson, Elisa De Franco, Siri Atma W. Greeley, Lisa R. Letourneau, Kathleen M. Gillespie, International DS-PNDM Consortium, Matthew N. Wakeling, Sian Ellard, Sarah E. Flanagan, Kashyap A. Patel, Andrew T. Hattersley

Diabetes Jul 2019, 68 (7) 1528-1535; DOI: 10.2337/db19-0045
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Genetic Variation Within the HLA-DRA1 Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes
Özkan Aydemir, Janelle A. Noble, Jeffrey A. Bailey, Åke Lernmark, Patrick Marsh, Agnes Andersson Svärd, Frank Bearoff, Elizabeth P. Blankenhorn, John P. Mordes, the Better Diabetes Diagnosis (BDD) Study Group

Diabetes Jul 2019, 68 (7) 1523-1527; DOI: 10.2337/db18-1128
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Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score
Suna Onengut-Gumuscu, Wei-Min Chen, Catherine C. Robertson, Jessica K. Bonnie, Emily Farber, Zhennan Zhu, Jorge R. Oksenberg, Steven R. Brant, S. Louis Bridges, Jeffrey C. Edberg, Robert P. Kimberly, Peter K. Gregersen, Marian J. Rewers, Andrea K. Steck, Mary H. Black, Dana Dabelea, Catherine Pihoker, Mark A. Atkinson, Lynne E. Wagenknecht, Jasmin Divers, Ronny A. Bell, SEARCH for Diabetes in Youth, Type 1 Diabetes Genetics Consortium, Henry A. Erlich, Patrick Concannon, Stephen S. Rich

Diabetes Care Mar 2019, 42 (3) 406-415; DOI: 10.2337/dc18-1727
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First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes
Diana L. Cousminer, Emma Ahlqvist, Rajashree Mishra, Mette K. Andersen, Alessandra Chesi, Mohammad I. Hawa, Asa Davis, Kenyaita M. Hodge, Jonathan P. Bradfield, Kaixin Zhou, Vanessa C. Guy, Mikael Åkerlund, Mette Wod, Lars G. Fritsche, Henrik Vestergaard, James Snyder, Kurt Højlund, Allan Linneberg, Annemari Käräjämäki, Ivan Brandslund, Cecilia E. Kim, Daniel Witte, Elin Pettersen Sørgjerd, David J. Brillon, Oluf Pedersen, Henning Beck-Nielsen, Niels Grarup, Richard E. Pratley, Michael R. Rickels, Adrian Vella, Fernando Ovalle, Olle Melander, Ronald I. Harris, Stephen Varvel, Valdemar E.R. Grill, Bone Mineral Density in Childhood Study, Hakon Hakonarson, Philippe Froguel, John T. Lonsdale, Didac Mauricio, Nanette C. Schloot, Kamlesh Khunti, Carla J. Greenbaum, Bjørn Olav Åsvold, Knud B. Yderstræde, Ewan R. Pearson, Stanley Schwartz, Benjamin F. Voight, Torben Hansen, Tiinamaija Tuomi, Bernhard O. Boehm, Leif Groop, R. David Leslie, Struan F.A. Grant

Diabetes Care Nov 2018, 41 (11) 2396-2403; DOI: 10.2337/dc18-1032
Open Access
Type 1 Diabetes in STAT Protein Family Mutations: Regulating the Th17/Treg Equilibrium and Beyond
Marco Fabbri, Mikaela Frixou, Massimo Degano, Georgia Fousteri

Diabetes Feb 2019, 68 (2) 258-265; DOI: 10.2337/db18-0627
Open Access
Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families
Markus Hippich, Andreas Beyerlein, William A. Hagopian, Jeffrey P. Krischer, Kendra Vehik, Jan Knoop, Christiane Winker, Jorma Toppari, Åke Lernmark, Marian J. Rewers, Andrea K. Steck, Jin-Xiong She, Beena Akolkar, Catherine C. Robertson, Suna Onengut-Gumuscu, Stephen S. Rich, Ezio Bonifacio, Anette-G. Ziegler, the TEDDY Study Group

Diabetes Apr 2019, 68 (4) 847-857; DOI: 10.2337/db18-0882
Open Access
Genetic Determinants of Glycated Hemoglobin in Type 1 Diabetes
Anna Syreeni, Niina Sandholm, Jingjing Cao, Iiro Toppila, David M. Maahs, Marian J. Rewers, Janet K. Snell-Bergeon, Tina Costacou, Trevor J. Orchard, M. Luiza Caramori, Michael Mauer, Barbara E.K. Klein, Ronald Klein, Erkka Valo, Maija Parkkonen, Carol Forsblom, Valma Harjutsalo, Andrew D. Paterson, for the DCCT/EDIC Research Group, Per-Henrik Groop

Diabetes Apr 2019, 68 (4) 858-867; DOI: 10.2337/db18-0573
Open Access
Genome-Wide Association Study Confirming a Strong Effect of HLA and Identifying Variants in CSAD/lnc-ITGB7-1 on Chromosome 12q13.13 Associated With Susceptibility to Fulminant Type 1 Diabetes
Yumiko Kawabata, Nao Nishida, Takuya Awata, Eiji Kawasaki, Akihisa Imagawa, Akira Shimada, Haruhiko Osawa, Shoichiro Tanaka, Kazuma Takahashi, Masao Nagata, Hisafumi Yasuda, Yasuko Uchigata, Hiroshi Kajio, Hideichi Makino, Kazuki Yasuda, Tetsuro Kobayashi, Toshiaki Hanafusa, Katsushi Tokunaga, Hiroshi Ikegami

Diabetes Mar 2019, 68 (3) 665-675; DOI: 10.2337/db18-0314

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