Genetics-Type 2 Diabetes

  • TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH)
    Shylaja Srinivasan, Varinderpal Kaur, Bindu Chamarthi, Katherine R. Littleton, Ling Chen, Alisa K. Manning, Jordi Merino, Melissa K. Thomas, Margo Hudson, Allison Goldfine, Jose C. Florez
    Diabetes Care Mar 2018, 41 (3) 554-561; DOI: 10.2337/dc17-1386
  • A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study
    Aino Latva-Rasku, Miikka-Juhani Honka, Alena Stančáková, Heikki A. Koistinen, Johanna Kuusisto, Li Guan, Alisa K. Manning, Heather Stringham, Anna L. Gloyn, Cecilia M. Lindgren, T2D-GENES Consortium, Francis S. Collins, Karen L. Mohlke, Laura J. Scott, Tomi Karjalainen, Lauri Nummenmaa, Michael Boehnke, Pirjo Nuutila, Markku Laakso
    Diabetes Feb 2018, 67 (2) 334-342; DOI: 10.2337/db17-1142
  • Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease
    Connor A. Emdin, Derek Klarin, Pradeep Natarajan, CARDIOGRAM Exome Consortium, Jose C. Florez, Sekar Kathiresan, Amit V. Khera
    Diabetes Aug 2017, 66 (8) 2310-2315; DOI: 10.2337/db17-0149
  • A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants
    Andrew R. Wood, Anna Jonsson, Anne U. Jackson, Nan Wang, Nienke van Leewen, Nicholette D. Palmer, Sayuko Kobes, Joris Deelen, Lorena Boquete-Vilarino, Jussi Paananen, Alena Stančáková, Dorret I. Boomsma, Eco J.C. de Geus, Elisabeth M.W. Eekhoff, Andreas Fritsche, Mark Kramer, Giel Nijpels, Annemarie Simonis-Bik, Timon W. van Haeften, Anubha Mahajan, Michael Boehnke, Richard N. Bergman, Jaakko Tuomilehto, Francis S. Collins, Karen L. Mohlke, Karina Banasik, Christopher J. Groves, Mark I. McCarthy, Diabetes Research on Patient Stratification (DIRECT), Ewan R. Pearson, Andrea Natali, Andrea Mari, Thomas A. Buchanan, Kent D. Taylor, Anny H. Xiang, Anette P. Gjesing, Niels Grarup, Hans Eiberg, Oluf Pedersen, Yii-Derr Chen, Markku Laakso, Jill M. Norris, Ulf Smith, Lynne E. Wagenknecht, Leslie Baier, Donald W. Bowden, Torben Hansen, Mark Walker, Richard M. Watanabe, Leen M. ‘t Hart, Robert L. Hanson, Timothy M. Frayling
    Diabetes Aug 2017, 66 (8) 2296-2309; DOI: 10.2337/db16-1452
  • Temporal Transcriptomic and Proteomic Landscapes of Deteriorating Pancreatic Islets in Type 2 Diabetic Rats
    Junjie Hou, Zonghong Li, Wen Zhong, Qiang Hao, Lei Lei, Linlin Wang, Dongyu Zhao, Pingyong Xu, Yifa Zhou, You Wang, Tao Xu
    Diabetes Aug 2017, 66 (8) 2188-2200; DOI: 10.2337/db16-1305
  • Open Access
    Response to Comment on Dubois-Laforgue et al. Diabetes, Associated Clinical Spectrum, Long-term Prognosis, and Genotype/Phenotype Correlations in 201 Adult Patients With Hepatocyte Nuclear Factor 1B (HNF1B) Molecular Defects. Diabetes Care 2017;40:1436–1443
    Danièle Dubois-Laforgue, Erika Cornu, Cécile Saint-Martin, Joël Coste, Christine Bellanné-Chantelot, José Timsit
    Diabetes Care Jan 2018, 41 (1) e8-e9; DOI: 10.2337/dci17-0048
  • A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes
    Jun Liu, Jan Bert van Klinken, Sabina Semiz, Ko Willems van Dijk, Aswin Verhoeven, Thomas Hankemeier, Amy C. Harms, Eric Sijbrands, Nuala A. Sheehan, Cornelia M. van Duijn, Ayşe Demirkan
    Diabetes Nov 2017, 66 (11) 2915-2926; DOI: 10.2337/db17-0199
  • A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes
    Josep M. Mercader, Rachel G. Liao, Avery D. Bell, Zachary Dymek, Karol Estrada, Taru Tukiainen, Alicia Huerta-Chagoya, Hortensia Moreno-Macías, Kathleen A. Jablonski, Robert L. Hanson, Geoffrey A. Walford, Ignasi Moran, Ling Chen, Vineeta Agarwala, María Luisa Ordoñez-Sánchez, Rosario Rodríguez-Guillen, Maribel Rodríguez-Torres, Yayoi Segura-Kato, Humberto García-Ortiz, Federico Centeno-Cruz, Francisco Barajas-Olmos, Lizz Caulkins, Sobha Puppala, Pierre Fontanillas, Amy L. Williams, Sílvia Bonàs-Guarch, Chris Hartl, Stephan Ripke, Diabetes Prevention Program Research Group, Katherine Tooley, Jacqueline Lane, Carlos Zerrweck, Angélica Martínez-Hernández, Emilio J. Córdova, Elvia Mendoza-Caamal, Cecilia Contreras-Cubas, María E. González-Villalpando, Ivette Cruz-Bautista, Liliana Muñoz-Hernández, Donaji Gómez-Velasco, Ulises Alvirde, Brian E. Henderson, Lynne R. Wilkens, Loic Le Marchand, Olimpia Arellano-Campos, Laura Riba, Maegan Harden, Broad Genomics Platform, Stacey Gabriel, T2D-GENES Consortium, Hanna E. Abboud, Maria L. Cortes, Cristina Revilla-Monsalve, Sergio Islas-Andrade, Xavier Soberon, Joanne E. Curran, Christopher P. Jenkinson, Ralph A. DeFronzo, Donna M. Lehman, Craig L. Hanis, Graeme I. Bell, Michael Boehnke, John Blangero, Ravindranath Duggirala, Richa Saxena, Daniel MacArthur, Jorge Ferrer, Steven A. McCarroll, David Torrents, William C. Knowler, Leslie J. Baier, Noel Burtt, Clicerio González-Villalpando, Christopher A. Haiman, Carlos A. Aguilar-Salinas, Teresa Tusié-Luna, Jason Flannick, Suzanne B.R. Jacobs, Lorena Orozco, David Altshuler, Jose C. Florez
    Diabetes Nov 2017, 66 (11) 2903-2914; DOI: 10.2337/db17-0187
  • An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
    Robert A. Scott, Laura J. Scott, Reedik Mägi, Letizia Marullo, Kyle J. Gaulton, Marika Kaakinen, Natalia Pervjakova, Tune H. Pers, Andrew D. Johnson, John D. Eicher, Anne U. Jackson, Teresa Ferreira, Yeji Lee, Clement Ma, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Lu Qi, Natalie R. Van Zuydam, Anubha Mahajan, Han Chen, Peter Almgren, Ben F. Voight, Harald Grallert, Martina Müller-Nurasyid, Janina S. Ried, Nigel W. Rayner, Neil Robertson, Lennart C. Karssen, Elisabeth M. van Leeuwen, Sara M. Willems, Christian Fuchsberger, Phoenix Kwan, Tanya M. Teslovich, Pritam Chanda, Man Li, Yingchang Lu, Christian Dina, Dorothee Thuillier, Loic Yengo, Longda Jiang, Thomas Sparso, Hans A. Kestler, Himanshu Chheda, Lewin Eisele, Stefan Gustafsson, Mattias Frånberg, Rona J. Strawbridge, Rafn Benediktsson, Astradur B. Hreidarsson, Augustine Kong, Gunnar Sigurðsson, Nicola D. Kerrison, Jian'an Luan, Liming Liang, Thomas Meitinger, Michael Roden, Barbara Thorand, Tõnu Esko, Evelin Mihailov, Caroline Fox, Ching-Ti Liu, Denis Rybin, Bo Isomaa, Valeriya Lyssenko, Tiinamaija Tuomi, David J. Couper, James S. Pankow, Niels Grarup, Christian T. Have, Marit E. Jørgensen, Torben Jørgensen, Allan Linneberg, Marilyn C. Cornelis, Rob M. van Dam, David J. Hunter, Peter Kraft, Qi Sun, Sarah Edkins, Katharine R. Owen, John R.B. Perry, Andrew R. Wood, Eleftheria Zeggini, Juan Tajes-Fernandes, Goncalo R. Abecasis, Lori L. Bonnycastle, Peter S. Chines, Heather M. Stringham, Heikki A. Koistinen, Leena Kinnunen, Bengt Sennblad, Thomas W. Mühleisen, Markus M. Nöthen, Sonali Pechlivanis, Damiano Baldassarre, Karl Gertow, Steve E. Humphries, Elena Tremoli, Norman Klopp, Julia Meyer, Gerald Steinbach, Roman Wennauer, Johan G. Eriksson, Satu Mӓnnistö, Leena Peltonen, Emmi Tikkanen, Guillaume Charpentier, Elodie Eury, Stéphane Lobbens, Bruna Gigante, Karin Leander, Olga McLeod, Erwin P. Bottinger, Omri Gottesman, Douglas Ruderfer, Matthias Blüher, Peter Kovacs, Anke Tonjes, Nisa M. Maruthur, Chiara Scapoli, Raimund Erbel, Karl-Heinz Jöckel, Susanne Moebus, Ulf de Faire, Anders Hamsten, Michael Stumvoll, Panagiotis Deloukas, Peter J. Donnelly, Timothy M. Frayling, Andrew T. Hattersley, Samuli Ripatti, Veikko Salomaa, Nancy L. Pedersen, Bernhard O. Boehm, Richard N. Bergman, Francis S. Collins, Karen L. Mohlke, Jaakko Tuomilehto, Torben Hansen, Oluf Pedersen, Inês Barroso, Lars Lannfelt, Erik Ingelsson, Lars Lind, Cecilia M. Lindgren, Stephane Cauchi, Philippe Froguel, Ruth J.F. Loos, Beverley Balkau, Heiner Boeing, Paul W. Franks, Aurelio Barricarte Gurrea, Domenico Palli, Yvonne T. van der Schouw, David Altshuler, Leif C. Groop, Claudia Langenberg, Nicholas J. Wareham, Eric Sijbrands, Cornelia M. van Duijn, Jose C. Florez, James B. Meigs, Eric Boerwinkle, Christian Gieger, Konstantin Strauch, Andres Metspalu, Andrew D. Morris, Colin N.A. Palmer, Frank B. Hu, Unnur Thorsteinsdottir, Kari Stefansson, Josée Dupuis, Andrew P. Morris, Michael Boehnke, Mark I. McCarthy, Inga Prokopenko
    Diabetes Nov 2017, 66 (11) 2888-2902; DOI: 10.2337/db16-1253
  • Haptoglobin 1-1 Genotype Modulates the Association of Glycemic Control With Hippocampal Volume in Elderly Individuals With Type 2 Diabetes
    Abigail Livny, Ramit Ravona-Springer, Anthony Heymann, Rachel Priess, Tammar Kushnir, Galia Tsarfaty, Leeron Rabinov, Reut Moran, Niv Tik, Erin Moshier, Itzik Cooper, Lior Greenbaum, Jeremy Silverman, Andrew Levy, Mary Sano, Barbara B. Bendlin, Aron S. Buchman, Michal Schnaider-Beeri
    Diabetes Nov 2017, 66 (11) 2927-2932; DOI: 10.2337/db16-0987

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