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Short Reports

Comparison of HbA1 and Fructosamine in Diagnosis of Glucose-Tolerance Abnormalities

  1. Pierre Jean Guillausseau, MD,
  2. Marie-Aline Charles, MD,
  3. Françoise Paolaggi, DPharm,
  4. José Timsit, MD,
  5. Philippe Chanson, MD,
  6. Jacqueline Peynet, DPharm,
  7. Valérie Godard, DPharm,
  8. Eveline Eschwege, MD,
  9. François Rousselet, DPharm and
  10. Jean Lubetzki, MD
  1. Departments of Internal Medicine and Biochemistry, Lariboisière Hospital Paris; and the National Institute of Health and Medical Research (INSERM) Unit 21, 94807 Villejuif, France
  1. Address correspondence and reprint requests to P.J. Guillausseau, MD, Lariboisière Hospital, Department of Internal Medicine, 2 Rue Ambroise Pare, 75475 Paris Cedex 10, France.
Diabetes Care 1990 Aug; 13(8): 898-900. https://doi.org/10.2337/diacare.13.8.898
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Abstract

Total glycosylated hemoglobin (HbA1) and fructosamine were evaluated as screening tools for detection of glucose-tolerance abnormalities in 144 asymptomatic subjects undergoing a 75-g oral glucose tolerance test. Subjects were classified according to World Health Organization criteria as having normal (n = 78), impaired (n = 40), or diabetic (n = 26) glucose tolerance. We found good specificity for HbA1 and fructosamine (100 and 97%, respectively) but low sensitivity (15 and 19%, respectively). At the intersection of the curves of sensitivity and specificity drawn from various thresholds of normality, both sensitivity and specificity were 75% for HbA1 and 55% for fructosamine. Thus, neither HbA1 nor fructosamine seems to be suitable for the diagnosis of mild abnormalities in glucose tolerance.

  • Received October 23, 1989.
  • Revision received March 21, 1990.
  • Accepted March 21, 1990.
  • Copyright © 1990 by the American Diabetes Association

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August 1990, 13(8)
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Comparison of HbA1 and Fructosamine in Diagnosis of Glucose-Tolerance Abnormalities
Pierre Jean Guillausseau, Marie-Aline Charles, Françoise Paolaggi, José Timsit, Philippe Chanson, Jacqueline Peynet, Valérie Godard, Eveline Eschwege, François Rousselet, Jean Lubetzki
Diabetes Care Aug 1990, 13 (8) 898-900; DOI: 10.2337/diacare.13.8.898

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Comparison of HbA1 and Fructosamine in Diagnosis of Glucose-Tolerance Abnormalities
Pierre Jean Guillausseau, Marie-Aline Charles, Françoise Paolaggi, José Timsit, Philippe Chanson, Jacqueline Peynet, Valérie Godard, Eveline Eschwege, François Rousselet, Jean Lubetzki
Diabetes Care Aug 1990, 13 (8) 898-900; DOI: 10.2337/diacare.13.8.898
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© 2021 by the American Diabetes Association. Diabetes Care Print ISSN: 0149-5992, Online ISSN: 1935-5548.