Relationship of Metabolic Control and Body Weight to Hypercholesterolemia in NIDDM Patients With Apolipoprotein E4

Masaaki Eto; Kiyoshi Watanabe; Isao Makino

doi:10.2337/diacare.14.2.127

Short Reports

Relationship of Metabolic Control and Body Weight to Hypercholesterolemia in NIDDM Patients With Apolipoprotein E4

Masaaki Eto, MD,
Kiyoshi Watanabe, MD and
Isao Makino, MD

Second Department of Internal Medicine, Asahikawa Medical College Asahikawa, Japan

Address correspondence and reprint requests to Masaaki Eto, MD, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, RG-26, University of Washington, Seattle, WA 98195.

Diabetes Care 1991 Feb; 14(2): 127-129. https://doi.org/10.2337/diacare.14.2.127

Abstract

Objective We previously reported that non-insulindependent diabetes mellitus (NIDDM) patients with apolipoprotein E4 (apoE4) are more susceptible to hypercholesterolemia. The purpose of this study was to clarify whether metabolic control or body weight is related to hypercholesterolemia in NIDDM patients with apoE4.

Research Design and Methods Two hundred forty NIDDM patients with apoE4 or apoE3/3 who had either hypercholesterolemia or normolipidemia were studied. ApoE phenotypes were determined by isoelectric focusing method.

Results The apoE4- carrying NIDDM patients with hypercholesterolemia (n = 39) showed significantly higher fasting plasma glucose (8.4 vs. 7.2 mM, P < 0.05), HbA, (9.3 vs. 8.1%, P < 0.05), and percentage of ideal body weight values (116 vs. 102%, P < 0.01) than the apoE4-carrying NIDDM patients with normolipidemia (n – 26), whereas there was no significant difference in their levels between the apoE3/3-carrying NIDDM patients with hypercholesterolemia (n = 47) and normolipidemia (n = 128).

Conclusions In addition to our previous finding, this study indicates that hypercholesterolemia in apoE4-carrying NIDDM patients may be more closely related to poor metabolic control and increased percentage of ideal body weight.