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Supplement 3: Diabetes in Hispanic Americans

Pathogenesis of NIDDM in Pima Indians

  1. Clifton Bogardus, MD,
  2. Stephen Lillioja, MB, ChB, FRACP and
  3. Peter H Bennett, MB, FRCP
  1. Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Phoenix, Arizona
  1. Address correspondence and reprint requests to Clifton Bogardus, MD, National Institutes of Health, 4212 North 16th Street, Room 541, Phoenix, AZ 85016.
Diabetes Care 1991 Jul; 14(7): 685-690. https://doi.org/10.2337/diacare.14.7.685
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Abstract

The Pima Indians of Arizona have the highest reported prevalence and incidence of non-insulin-dependent diabetes mellitus (NIDDM) of any population in the world. A cross-sectional and longitudinal study was begun in 1982 to determine the metabolic characteristic(s) that is (are) predictive of the development of NIDDM and to document the sequence of metabolic events that occur with the transition from normal to impaired glucose tolerance and then to diabetes. Preliminary analyses suggest that insulin resistance is a primary abnormality predisposing Pima Indians to develop impaired glucose tolerance, and that the development of diabetes occurs with subsequent pancreatic failure.

  • Copyright © 1991 by the American Diabetes Association

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July 1991, 14(7)
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Pathogenesis of NIDDM in Pima Indians
Clifton Bogardus, Stephen Lillioja, Peter H Bennett
Diabetes Care Jul 1991, 14 (7) 685-690; DOI: 10.2337/diacare.14.7.685

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Pathogenesis of NIDDM in Pima Indians
Clifton Bogardus, Stephen Lillioja, Peter H Bennett
Diabetes Care Jul 1991, 14 (7) 685-690; DOI: 10.2337/diacare.14.7.685
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  • Prevalence Rates for Diabetes Mellitus in Puerto Rico
  • Obesity in Hispanic Americans
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© 2021 by the American Diabetes Association. Diabetes Care Print ISSN: 0149-5992, Online ISSN: 1935-5548.