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Short Reports

Increased Plasma Endothelin in NIDDM Patients With Retinopathy

  1. Makiko Kawamura, MD,
  2. Hisako Ohgawara, MD,
  3. Mitsuhide Naruse, MD,
  4. Nobuhiro Suzuki, PHD,
  5. Naoko Iwasaki, MD,
  6. Kiyoko Naruse, MD,
  7. Sadao Hori, MD,
  8. Hiroshi Demura, MD and
  9. Yasue Omori, MD
  1. Diabetes Center, Department of Medicine, and Diabetic Ophthalmology, Institute of Clinical Endocrinology, Department of Medicine, Tokyo Women's Medical College Tokyo; and the Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd. Tsukuba, Ibaraki, Japan
  1. Address Correspondence and reprint requests to Dr. Makiko Kawamura, Department of Medicine, Diabetes Center, Tokyo Women's Medical College, 8–1 Kawadacho, Shinjuku-Ku, Tokyo 162, Japan.
Diabetes Care 1992 Oct; 15(10): 1396-1397. https://doi.org/10.2337/diacare.15.10.1396
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Abstract

OBJECTIVE To elucidate the significance of ET in diabetic microvascular disease.

RESEARCH DESIGN AND METHODS We determined plasma levels of ir-ET-1 in 25 NIDDM patients without hypertension and/or renal dysfunction.

RESULTS The plasma levels of ir-ET-1 in NIDDM patients with simple (n = 8) and proliferative (n = 8) retinopathy were 0.58 ± 0.04 pM and 0.60 ± 0.04 pM, respectively, which were significantly higher than those in normal, nondiabetic subjects (0.24 ± 0.02 pM [n = 31]) and NIDDM patients without retinopathy (0.30 ± 0.05 pM [n = 9]).

CONCLUSIONS These results suggest that plasma ET-1 is related to diabetic microvascular disease.

  • Received June 3, 1991.
  • Accepted February 18, 1992.
  • Copyright © 1992 by the American Diabetes Association

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October 1992, 15(10)
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Increased Plasma Endothelin in NIDDM Patients With Retinopathy
Makiko Kawamura, Hisako Ohgawara, Mitsuhide Naruse, Nobuhiro Suzuki, Naoko Iwasaki, Kiyoko Naruse, Sadao Hori, Hiroshi Demura, Yasue Omori
Diabetes Care Oct 1992, 15 (10) 1396-1397; DOI: 10.2337/diacare.15.10.1396

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Increased Plasma Endothelin in NIDDM Patients With Retinopathy
Makiko Kawamura, Hisako Ohgawara, Mitsuhide Naruse, Nobuhiro Suzuki, Naoko Iwasaki, Kiyoko Naruse, Sadao Hori, Hiroshi Demura, Yasue Omori
Diabetes Care Oct 1992, 15 (10) 1396-1397; DOI: 10.2337/diacare.15.10.1396
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