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Original Articles

Reproductive History, Glucose Tolerance, and NIDDM in Hispanic and Non-Hispanic White Women: The San Luis Valley Diabetes Study

  1. Beth W Alderman, MD, MPH,
  2. Julie A Marshall, PHD,
  3. Edward J Boyko, MD, MPH,
  4. Kathleen A Markham, MSPH,
  5. Judith Baxter, MA and
  6. Richard F Hamman, MD, PHD
  1. Department of Epidemiology, University of Washington School of Public Health Seattle Department of Medicine, University of Washington School of Medicine and Medical Service, Veterans Affairs Hospital Medical Center Seattle, Washington Department of Preventive Medicine and Biometrics, University of Colorado School of Medicine Denver, Colorado
  1. Address correspondence and reprint requests to Beth W. Alderman, MD, MPH, Department of Epidemiology, SC-36, University of Washington School of Public Health, Seattle, WA 98195.
Diabetes Care 1993 Dec; 16(12): 1557-1564. https://doi.org/10.2337/diacare.16.12.1557
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Abstract

OBJECTIVE To ascertain whether childbearing would decrease oral glucosestimulated insulin and C-peptide levels and increase the risk of NIDDM and impaired glucose tolerance in a population of Hispanic and non-Hispanic white women residing in the San Luis Valley of Colorado. Several investigators have related childbearing to subsequent abnormal glucose tolerance.

RESEARCH DESIGN AND METHODS In a population-based case-control epidemiological study, diabetic patients 20–74 yr of age (n = 196) and randomly sampled control women subjects (n = 735) underwent a glucose tolerance test, a physical examination, and an in-person standardized interview. The relations between the live-birth number and fasting and oral glucose stimulated glucose, insulin and C-peptide concentrations, and NIDDM and impaired glucose tolerance were estimated using linear or logistic regression to adjust for extraneous variables.

RESULTS In women selected as control subjects, the live-birth number was related to a significant decrease in the sum of 1- and 2-h C-peptide concentrations (coefficient = −0.077, P <0.001) and the logarithm of the sum of 1- and 2-h insulin concentrations (coefficient = −0.014, P = 0.02). After adjustment for subscapular skin-fold thickness, the relative odds of NIDDM for the live-birth number, which was small and of borderline significance, diminished (odds ratio = 1.04 for one birth, P = 0.18). Findings were similar for impaired glucose tolerance.

CONCLUSIONS Childbearing was related to lower C-peptide and insulin levels in Hispanic and non-Hispanic women of the San Luis Valley. It had little apparent effect on later risk of NIDDM or impaired glucose tolerance.

  • Received November 23, 1993.
  • Revision received May 27, 1993.
  • Accepted May 27, 1993.
  • Copyright © 1993 by the American Diabetes Association

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December 1993, 16(12)
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Reproductive History, Glucose Tolerance, and NIDDM in Hispanic and Non-Hispanic White Women: The San Luis Valley Diabetes Study
Beth W Alderman, Julie A Marshall, Edward J Boyko, Kathleen A Markham, Judith Baxter, Richard F Hamman
Diabetes Care Dec 1993, 16 (12) 1557-1564; DOI: 10.2337/diacare.16.12.1557

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Reproductive History, Glucose Tolerance, and NIDDM in Hispanic and Non-Hispanic White Women: The San Luis Valley Diabetes Study
Beth W Alderman, Julie A Marshall, Edward J Boyko, Kathleen A Markham, Judith Baxter, Richard F Hamman
Diabetes Care Dec 1993, 16 (12) 1557-1564; DOI: 10.2337/diacare.16.12.1557
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