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Short Reports

Urinary chiro-Inositol Excretion is an Index Marker of Insulin Sensitivity in Japanese Type II Diabetes

  1. Susumu Suzuki, MD,
  2. Hiromasa Kawasaki, MD,
  3. Yoshinori Satoh, MD,
  4. Masataka Ohtomo, MD,
  5. Masashi Hirai, MD,
  6. Aki Hirai, MD,
  7. Satoshi Hirai, MD,
  8. Masatoshi Onoda, MD,
  9. Masahiro Matsumoto, MD,
  10. Yoshinori Hinokio, MD,
  11. Hiroaki Akai, MD,
  12. James Craig, MD,
  13. Joseph Larner, MD, PHD and
  14. Takayoshi Toyota, MD
  1. Third Department of Internal Medicine, Tohoku University School of Medicine Sendai, Japan; and the Department of Pharmacology, University of Virginia School of Medicine Charlottesville, Virginia
  1. Address correspondence and reprint requests to Susumu Suzuki, MD, Third Department of Internal Medicine, Tohoku University School of Medicine, 1–1 Seiryou-machi, Aoba-ku, 980–77 Sendai, Japan.
Diabetes Care 1994 Dec; 17(12): 1465-1468. https://doi.org/10.2337/diacare.17.12.1465
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Abstract

OBJECTIVE To determine the relationship between urinary chiro-inositol excretion and insulin sensitivity in Japanese type II diabetic patients.

RESEARCH DESIGN AND METHODS Eighteen subjects were age-matched, nonobese, type II diabetic patients. Eight subjects had impaired glucose tolerance (IGT), and 10 had normal glucose tolerance (NGT). We quantified urinary chiro-inositol excretion using gas chromatography-mass spectrometry and the insulin sensitivity index (SI), and glucose effectiveness (SG) using Bergman's modified minimal model method.

RESULTS The urinary excretion of chiro-inositol was much lower in the diabetic patients (32.3 ± 16.0 μmol/day, means ± SD) than in the NGT subjects (96.0 ± 17.6; P < 0.0001) and IGT subjects (58.9 ± 11.6; P < 0.0001). SI was much lower in the diabetic patients (3.81 ± 1.49) than in the NGT subjects 6.30 ± 1.59, P < 0.0005). SG was much lower in the diabetic patients (2.14 ± 0.56) than in the NGT subjects (3.07 ± 0.38, P < 0.0001). There was a significant correlation between urinary chiro-inositol excretion and SI (r = 0.766), as well as a significant correlation between urinary chiro-inositol excretion and SG (r = 0.747).

CONCLUSIONS There is a direct relationship of urinary chiro-inositol excretion to insulin sensitivity and SG in humans. Urinary chiro-inositol excretion might be useful as a metabolic index of insulin sensitivity in type II diabetes.

  • Received April 8, 1994.
  • Revision received June 30, 1994.
  • Accepted June 30, 1994.
  • Copyright © 1994 by the American Diabetes Association

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December 1994, 17(12)
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Urinary chiro-Inositol Excretion is an Index Marker of Insulin Sensitivity in Japanese Type II Diabetes
Susumu Suzuki, Hiromasa Kawasaki, Yoshinori Satoh, Masataka Ohtomo, Masashi Hirai, Aki Hirai, Satoshi Hirai, Masatoshi Onoda, Masahiro Matsumoto, Yoshinori Hinokio, Hiroaki Akai, James Craig, Joseph Larner, Takayoshi Toyota
Diabetes Care Dec 1994, 17 (12) 1465-1468; DOI: 10.2337/diacare.17.12.1465

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Urinary chiro-Inositol Excretion is an Index Marker of Insulin Sensitivity in Japanese Type II Diabetes
Susumu Suzuki, Hiromasa Kawasaki, Yoshinori Satoh, Masataka Ohtomo, Masashi Hirai, Aki Hirai, Satoshi Hirai, Masatoshi Onoda, Masahiro Matsumoto, Yoshinori Hinokio, Hiroaki Akai, James Craig, Joseph Larner, Takayoshi Toyota
Diabetes Care Dec 1994, 17 (12) 1465-1468; DOI: 10.2337/diacare.17.12.1465
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