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Original Articles

Muscle Fiber Composition and Capillary Density in Women and Men With NIDDM

  1. Per MÅrin, MD, PHD,
  2. Björn Andersson, MD, PHD,
  3. Marcin Krotkiewski, MD, PHD and
  4. Per Björntorp, MD, PHD
  1. Departments of Medicine, Sahlgren's Hospital, University of Göteborg Sweden
  2. Rehabilitation Medicine, Sahlgren's Hospital, University of Göteborg Sweden
  3. Heart and Lung Diseases, Sahlgren's Hospital, University of Göteborg Sweden
  1. Address correspondence and reprint requests to Per Björntorp, MD, PhD, Department of Heart and Lung Diseases, Sahlgren's Hospital, 413 45 Göteborg, Sweden.
Diabetes Care 1994 May; 17(5): 382-386. https://doi.org/10.2337/diacare.17.5.382
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Abstract

OBJECTIVE To determine whether muscle fiber composition and capillary density differed between diabetic and nondiabetic subjects.

RESEARCH DESIGN AND METHODS Muscle fiber composition and capillary density were determined in biopsies from women and men with non-insulindependent diabetes mellitus (NIDDM) and compared with those of control subjects matched for gender, age, obesity, and the waist-to-hip ratio, which are all factors known to influence muscle morphology.

RESULTS Patients with NIDDM, as well as control subjects with abdominal obesity and insulin resistance, showed the same abnormalities in muscle morphology, namely, a low percentage of type I fibers, elevated type II (particularly type IIB) fibers, and a low capillary density. These changes correlated closely with insulin concentrations in both diabetic and nondiabetic groups.

CONCLUSIONS Recent information suggests that insulin may regulate myosin synthesis in muscle in the direction of the changes observed. Therefore, it is possible that muscle fiber composition abnormalities in insulin-resistant conditions are secondary to hyperinsulinemia. However, the low capillary density, hypothetically, may contribute to insulin resistance.

  • Received January 12, 1993.
  • Accepted September 30, 1993.
  • Copyright © 1994 by the American Diabetes Association

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May 1994, 17(5)
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Muscle Fiber Composition and Capillary Density in Women and Men With NIDDM
Per MÅrin, Björn Andersson, Marcin Krotkiewski, Per Björntorp
Diabetes Care May 1994, 17 (5) 382-386; DOI: 10.2337/diacare.17.5.382

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Muscle Fiber Composition and Capillary Density in Women and Men With NIDDM
Per MÅrin, Björn Andersson, Marcin Krotkiewski, Per Björntorp
Diabetes Care May 1994, 17 (5) 382-386; DOI: 10.2337/diacare.17.5.382
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