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Original Articles

Development of a Miniaturized Glucose Monitoring System by Combining a Needle-Type Glucose Sensor With Microdialysis Sampling Method: Long-term subcutaneous tissue glucose monitoring in ambulatory diabetic patients

  1. Yasuhiro Hashiguchi, MD,
  2. Michiharu Sakakida, MD, PHD,
  3. Kenro Nishida, MD,
  4. Takero Uemura, MD,
  5. Ken-Ichiro Kajiwara, MD, PHD and
  6. Motoaki Shichiri, MD, PHD
  1. Department of Metabolic Medicine, Kumamoto University School of Medicine Kumamoto, Japan
  1. Address correspondence and reprint requests to Yasuhiro Hashiguchi, MD, Department of Metabolic Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860, Japan.
Diabetes Care 1994 May; 17(5): 387-396. https://doi.org/10.2337/diacare.17.5.387
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Abstract

OBJECTIVE To develop a reliable and practical glucose monitoring system by combining a needle-type glucose sensor with a microdialysis sampling technique for long-term subcutaneous tissue glucose measurements.

RESEARCH DESIGN AND METHODS A microdialysis Cuprophan hollowfiber probe (inner diameter, 0.20 mm; length, 15 mm) was perfused with isotonic saline solution (120 μl/h) and glucose concentrations in the dialysate were measured by a needle-type glucose sensor extracorporeally. This system was tested both in vitro and in vivo. Subcutaneous tissue glucose concentrations were then monitored continuously in 5 healthy and 8 diabetic volunteers for 7 to 8 days. A hollow-fiber probe was inserted into the abdominal subcutaneous tissue.

RESULTS This monitoring system achieved excellent results in vitro. Subcutaneous tissue glucose concentrations were measured in a wide range from 1.7 to >027.8 mM glucose, with a time delay of 6.9 ±1.2 min associated with a rise in glucose and 8.8 ±1.6 min with a fall in the glucose level (means ± SE). The overall correlation between subcutaneous tissue (Y) and blood (X) glucose concentration was Y = 1.08X ± 0.19 (r = 0.99). The subcutaneous tissue glucose concentration could be monitored precisely for 4 days without any in vivo calibrations and for 7 days by introducing in vivo calibrations.

CONCLUSIONS Glycemic excursions could be monitored precisely in the subcutaneous tissue by this microdialysis sampling method with a needle-type glucose sensor in ambulatory diabetic patients.

  • Received April 5, 1993.
  • Accepted November 18, 1993.
  • Copyright © 1994 by the American Diabetes Association

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May 1994, 17(5)
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Development of a Miniaturized Glucose Monitoring System by Combining a Needle-Type Glucose Sensor With Microdialysis Sampling Method: Long-term subcutaneous tissue glucose monitoring in ambulatory diabetic patients
Yasuhiro Hashiguchi, Michiharu Sakakida, Kenro Nishida, Takero Uemura, Ken-Ichiro Kajiwara, Motoaki Shichiri
Diabetes Care May 1994, 17 (5) 387-396; DOI: 10.2337/diacare.17.5.387

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Development of a Miniaturized Glucose Monitoring System by Combining a Needle-Type Glucose Sensor With Microdialysis Sampling Method: Long-term subcutaneous tissue glucose monitoring in ambulatory diabetic patients
Yasuhiro Hashiguchi, Michiharu Sakakida, Kenro Nishida, Takero Uemura, Ken-Ichiro Kajiwara, Motoaki Shichiri
Diabetes Care May 1994, 17 (5) 387-396; DOI: 10.2337/diacare.17.5.387
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