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Short Reports

Prevalence and Determinants of Glucose Intolerance in a Dutch Caucasian Population: The Hoorn Study

  1. Johanna M Mooy, MD,
  2. Peter A Grootenhuis, MD, PHD,
  3. Hendrik de Vries, MD, PHD,
  4. Hans A Valkenburg, MD, PHD,
  5. Lex M Bouter, PHD,
  6. Pieter J Kostense, PHD and
  7. Robert J Heine, MD, PHD
  1. Institute for Research in Extramural Medicine, Vrije Universiteit Amsterdam, the Netherlands
  2. Department of General Practice and Nursing Home Medicine, Vrije Universiteit Amsterdam, the Netherlands
  3. Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, the Netherlands
  4. Department of Internal Medicine, Vrije Universiteit Amsterdam, the Netherlands
  1. Address correspondence and reprint request to Johanna M. Mooy, MD, Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands. E-mail: jm.mooy.emgo{at}med.vu.nl
Diabetes Care 1995 Sep; 18(9): 1270-1273. https://doi.org/10.2337/diacare.18.9.1270
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Abstract

OBJECTIVE To study the prevalence and determinants of glucose intolerance in a general Caucasian population.

RESEARCH DESIGN AND METHODS A random sample of 50- to 74-year old Caucasians (n = 2,484) underwent oral glucose tolerance tests. Multiple regression analyses were performed to study the association of 2-h postload plasma glucose values with potential determinants.

RESULTS Prevalence of known and newly detected diabetes and impaired glucose tolerance was 3.6, 4.8, and 10.3%, respectively. In women, but not in men, the association of body mass index with 2-h glucose was fully accounted for by the waist-to-hip ratio. Maternal history of diabetes was twice as prevalent as paternal history, but paternal history only was associated with 2-h glucose. In addition, paternal history was a stronger determinant in men than in women. An independent positive association with 2-h plasma glucose was found for alcohol use of > 30 g/day in women and for intake of total protein, animal protein, and polyunsaturated fatty acids in men. An independent inverse association with 2-h plasma glucose was demonstrated for height (both sexes), alcohol use of ≤ 30 g/day (both sexes), energy intake (in men), and, unexpectedly, current smoking (in men).

CONCLUSIONS The prevalence of diabetes in elderly Caucasians was 8.3%. In men, dietary habits may unfavorably influence glucose tolerance independent of obesity.

  • Received January 11, 1995.
  • Revision received May 25, 1995.
  • Accepted May 25, 1995.
  • Copyright © 1995 by the American Diabetes Association
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Prevalence and Determinants of Glucose Intolerance in a Dutch Caucasian Population: The Hoorn Study
Johanna M Mooy, Peter A Grootenhuis, Hendrik de Vries, Hans A Valkenburg, Lex M Bouter, Pieter J Kostense, Robert J Heine
Diabetes Care Sep 1995, 18 (9) 1270-1273; DOI: 10.2337/diacare.18.9.1270

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Prevalence and Determinants of Glucose Intolerance in a Dutch Caucasian Population: The Hoorn Study
Johanna M Mooy, Peter A Grootenhuis, Hendrik de Vries, Hans A Valkenburg, Lex M Bouter, Pieter J Kostense, Robert J Heine
Diabetes Care Sep 1995, 18 (9) 1270-1273; DOI: 10.2337/diacare.18.9.1270
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