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Elevated remnant-like lipoprotein particles in impaired glucose tolerance and type 2 diabetic patients.

  1. N Watanabe,
  2. T Taniguchi,
  3. H Taketoh,
  4. Y Kitagawa,
  5. H Namura,
  6. N Yoneda,
  7. Y Kurimoto,
  8. S Yamada and
  9. Y Ishikawa
  1. Health Care and Promotion Center, Yodogawa Christian Hospital, Osaka, Japan.
    Diabetes Care 1999 Jan; 22(1): 152-156. https://doi.org/10.2337/diacare.22.1.152
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    Abstract

    OBJECTIVE: Impaired glucose tolerance (IGT) in association with insulin resistance is considered to be a risk factor for atherosclerosis. Thus, patients with IGT may have abnormal lipid and lipoprotein profiles. The purpose of this study was to investigate presence of remnant-type hyperlipoproteinemia in patients with IGT. RESEARCH DESIGN AND METHODS: Serum levels of remnant-like lipoprotein particles (RLP) were measured in 541 subjects (362 men and 179 women, age 53 +/- 7.9 years) who visited our health center for routine medical examinations. We measured RLP cholesterol (RLP-C) and RLP triglycerides (RLP-TG) using immunoaffinity gel containing monoclonal anti-human apoproteins A-I (H-12) and B-100 (JI-H) antibodies. After a 75-g oral glucose tolerance test, subjects were divided into three groups: normal, IGT, and type 2 diabetic. RESULTS: After matching for sex, age, and body weight, serum RLP-C in normal, IGT, and diabetic groups were 4.2 +/- 1.7, 6.2 +/- 3.4, and 6.2 +/- 4.2 mg/dl, respectively. The corresponding RLP-TG values were 16.7 +/- 9.2, 28.0 +/- 19.1, and 29.0 +/- 27.2 mg/dl. We found that RLP-C and RLP-TG values were significantly higher in the IGT and diabetic groups compared with the normal group (P < 0.001). In the same order, total serum cholesterol levels were 206 +/- 29, 205 +/- 34, and 206 +/- 34 mg/dl and LDL cholesterol levels were 127 +/- 27, 124 +/- 34, and 123 +/- 34 mg/dl, showing no marked difference in these groups. However, serum levels of triglyceride were higher in the IGT and diabetes groups (155 +/- 76 and 151 +/- 81 mg/dl vs. 106 +/- 41 mg/dl; P < 0.0001). Further, the incidence of remnant hyperlipoproteinemia in normocholesterolemic subjects was up to four times higher in IGT and diabetic groups compared with the normal group. CONCLUSIONS: High serum RLP-C and RLP-TG levels in IGT and diabetic patients may represent an increased risk of atherosclerosis in these patients.

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    January 1999, 22(1)
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    Elevated remnant-like lipoprotein particles in impaired glucose tolerance and type 2 diabetic patients.
    N Watanabe, T Taniguchi, H Taketoh, Y Kitagawa, H Namura, N Yoneda, Y Kurimoto, S Yamada, Y Ishikawa
    Diabetes Care Jan 1999, 22 (1) 152-156; DOI: 10.2337/diacare.22.1.152

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    Elevated remnant-like lipoprotein particles in impaired glucose tolerance and type 2 diabetic patients.
    N Watanabe, T Taniguchi, H Taketoh, Y Kitagawa, H Namura, N Yoneda, Y Kurimoto, S Yamada, Y Ishikawa
    Diabetes Care Jan 1999, 22 (1) 152-156; DOI: 10.2337/diacare.22.1.152
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