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Fasting blood glucose: an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men.

  1. J V Bjørnholt,
  2. G Erikssen,
  3. E Aaser,
  4. L Sandvik,
  5. S Nitter-Hauge,
  6. J Jervell,
  7. J Erikssen and
  8. E Thaulow
  1. Medical Department, Rikshospitalet, Oslo, Norway.
    Diabetes Care 1999 Jan; 22(1): 45-49. https://doi.org/10.2337/diacare.22.1.45
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    Abstract

    OBJECTIVE: Because of the available conflicting epidemiological data, we investigated the possible impact of fasting blood glucose as a risk factor for cardiovascular death in nondiabetic men. This study reports the results from a 22-year prospective study on fasting blood glucose as a predictor of cardiovascular death. RESEARCH DESIGN AND METHODS: Of the 1,998 apparently healthy nondiabetic men (aged 40-59 years), a total of 1,973 with fasting blood glucose < 110 mg/dl were included in the study in which also a number of conventional risk factors were measured at baseline. RESULTS: After 22 years of follow-up, 483 men had died, 53% from cardiovascular diseases. After dividing men into quartiles of fasting blood glucose level, it was found that men in the highest glucose quartile (fasting blood glucose > 85 mg/dl) had a significantly higher mortality rate from cardiovascular diseases compared with those in the three lowest quartiles. Even after adjusting for age, smoking habits, serum lipids, blood pressure, forced expiratory volume in 1 s, and physical fitness (Cox model), the relative risk of cardiovascular death for men with fasting blood glucose > 85 mg/dl remained 1.4 (95% CI 1.04-1.8). Noncardiovascular deaths were unrelated to fasting blood glucose level. CONCLUSIONS: Fasting blood glucose values in the upper normal range appears to be an important independent predictor of cardiovascular death in nondiabetic apparently healthy middle-aged men.

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    January 1999, 22(1)
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    Fasting blood glucose: an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men.
    J V Bjørnholt, G Erikssen, E Aaser, L Sandvik, S Nitter-Hauge, J Jervell, J Erikssen, E Thaulow
    Diabetes Care Jan 1999, 22 (1) 45-49; DOI: 10.2337/diacare.22.1.45

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    Fasting blood glucose: an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men.
    J V Bjørnholt, G Erikssen, E Aaser, L Sandvik, S Nitter-Hauge, J Jervell, J Erikssen, E Thaulow
    Diabetes Care Jan 1999, 22 (1) 45-49; DOI: 10.2337/diacare.22.1.45
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