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Low birth weight, family history of diabetes, and glucose intolerance in Swedish middle-aged men.

  1. S Carlsson,
  2. P G Persson,
  3. M Alvarsson,
  4. S Efendic,
  5. A Norman,
  6. L Svanström,
  7. C G Ostenson and
  8. V Grill
  1. Division of Epidemiology, Karolinska University Hospital, Stockholm, Sweden. sofia.carlsson@imm.ki.se
    Diabetes Care 1999 Jul; 22(7): 1043-1047. https://doi.org/10.2337/diacare.22.7.1043
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    Abstract

    OBJECTIVE: To investigate the association between low birth weight and glucose intolerance in relation to family history of diabetes. RESEARCH DESIGN AND METHODS: We conducted a population-based cross-sectional study of 2,237 men born in 1938-1957 in four municipalities in the outskirts of Stockholm, 50% of whom had a family history of diabetes (at least one first-degree or two second-degree relatives with diabetes). Oral glucose tolerance testing detected 35 cases of type 2 diabetes, 102 cases of impaired glucose tolerance, and 57 cases of impaired fasting glucose. RESULTS: In subjects without a family history of diabetes, low (< or = 3,000 g) birth weight was associated with an odds ratio of 2.3 (95% confidence intervals = 0.4-14.4) for diabetes, 1.8 (0.7-4.3) for impaired glucose tolerance, and 3.3 (1.0-10.4) for impaired fasting glucose. In subjects with a family history of diabetes, the corresponding figures were approximately similar, except for diabetes, for which the odds ratio was 5.4 (2.0-14.9). For men with low birth weight in combination with a family history of diabetes, the odds ratio was 10.9 (2.9-41.2) for diabetes, 2.4 (1.1-5.6) for impaired glucose tolerance, and 5.9 (2.1-16.3) for impaired fasting glucose. CONCLUSIONS: This study indicated that low birth weight is associated with type 2 diabetes, impaired glucose tolerance, and impaired fasting glucose in men. This finding was most pronounced in subjects with diabetes in the family, but it was also indicated in those without a family history of diabetes. Men with the combination of low birth weight and family history of diabetes seem to be at particularly high risk of developing type 2 diabetes.

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    July 1999, 22(7)
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    Low birth weight, family history of diabetes, and glucose intolerance in Swedish middle-aged men.
    S Carlsson, P G Persson, M Alvarsson, S Efendic, A Norman, L Svanström, C G Ostenson, V Grill
    Diabetes Care Jul 1999, 22 (7) 1043-1047; DOI: 10.2337/diacare.22.7.1043

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    Low birth weight, family history of diabetes, and glucose intolerance in Swedish middle-aged men.
    S Carlsson, P G Persson, M Alvarsson, S Efendic, A Norman, L Svanström, C G Ostenson, V Grill
    Diabetes Care Jul 1999, 22 (7) 1043-1047; DOI: 10.2337/diacare.22.7.1043
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