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Postchallenge plasma glucose and glycemic spikes are more strongly associated with atherosclerosis than fasting glucose or HbA1c level.

  1. T S Temelkova-Kurktschiev,
  2. C Koehler,
  3. E Henkel,
  4. W Leonhardt,
  5. K Fuecker and
  6. M Hanefeld
  1. Institute for Clinical Metabolic Research, Technical Univeristy Dresden, Germany.
    Diabetes Care 2000 Dec; 23(12): 1830-1834. https://doi.org/10.2337/diacare.23.12.1830
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    Abstract

    OBJECTIVE: To observe the relationship of fasting plasma glucose (FPG), postchallenge plasma glucose (PG) (30, 60, 90, and 120 min during an oral glucose tolerance test [OGTT], as well as maximal PG during an OGTT, postchallenge glucose spikes [PGS], and glucose under the OGTT curve), and HbA1c to intima-media thickness (IMT) as a marker of atherosclerosis. RESEARCH DESIGN AND METHODS: OGTT, ultrasound measurement of carotid IMT, and various atherosclerosis risk factors, such as family history of diabetes, obesity, and/or hyperlipoproteinemia, but without known diabetes, were analyzed in 582 individuals aged 40-70 years and at risk for type 2 diabetes. RESULTS: In univariate analysis, all examined glycemic parameters were significantly correlated to IMT. The 2-h postchallenge plasma glucose showed the strongest odds ratio (OR) of 1.88 (1.34-2.63) in relation to abnormal IMT. All PG variables, except for 30-min glucose in OGTT, showed a significant OR, whereas the OR for HbA1c and FPG was not significant. In logistic regression analysis, 2-h PG was identified as the strongest determinant of IMT from all glycemic parameters. The 2-h PG and PGS, but not FPG, were associated with a significant rise of IMT in tertiles of HbA1c. Glycemic parameters were strongly related to each other and to many atherosclerosis risk factors. In multivariate analysis including a variety of atherosclerosis risk factors, 2-h PG was a significant independent determinant of IMT. CONCLUSIONS: PG and PGS are more strongly associated with carotid IMT than FPG and HbA1c level and modify substantially the risk for atherosclerosis, estimated by HbA1c alone, in a cohort at risk for diabetes and in the early diabetes stage.

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    December 2000, 23(12)
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    Postchallenge plasma glucose and glycemic spikes are more strongly associated with atherosclerosis than fasting glucose or HbA1c level.
    T S Temelkova-Kurktschiev, C Koehler, E Henkel, W Leonhardt, K Fuecker, M Hanefeld
    Diabetes Care Dec 2000, 23 (12) 1830-1834; DOI: 10.2337/diacare.23.12.1830

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    Postchallenge plasma glucose and glycemic spikes are more strongly associated with atherosclerosis than fasting glucose or HbA1c level.
    T S Temelkova-Kurktschiev, C Koehler, E Henkel, W Leonhardt, K Fuecker, M Hanefeld
    Diabetes Care Dec 2000, 23 (12) 1830-1834; DOI: 10.2337/diacare.23.12.1830
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