Effectiveness of Platelet Releasate for the Treatment of Diabetic Neuropathic Foot Ulcers

David J. Margolis; Jonathan Kantor; Jill Santanna; Brian L. Strom; Jesse A. Berlin

doi:10.2337/diacare.24.3.483

Emerging Treatments and Technologies

Effectiveness of Platelet Releasate for the Treatment of Diabetic Neuropathic Foot Ulcers

David J. Margolis, MD, MSCE1 2,
Jonathan Kantor, MA2,
Jill Santanna, MS2,
Brian L. Strom, MD, MPH2 and
Jesse A. Berlin, SCD2

¹Dermatology and
²Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Diabetes Care 2001 Mar; 24(3): 483-488. https://doi.org/10.2337/diacare.24.3.483

Article Figures & Tables

Tables

Table 1 —

Selected characteristics of the study population by PR status

	No PR	PR
n	20,347	6,252
Sex (% male)	53.7 (53.0–54.4)	56.7 (55.4–57.9)
Age (years)	64.2 (64.0–64.4)	63.1 (62.7–63.4)
Wound area (mm²)	716.4 (674.4–758.4)	981.7 (910.8–1,052.5)
Wound duration (months)	9.1 (8.8–9.5)	9.95 (9.31–10.59)
Wound grade	2.47 (2.45–2.48)	2.68 (2.65–2.70)
Wound volume (mm³)	6,870.4 (5,155.4–8,585.3)	13,153.6 (10,914.2–15,392.9)
Insurance (%)	82.3 (81.8–82.8)	84.9 (84.0–85.8)
Clinic age (months)	36.7 (36.4–37.1)	32.4 (31.8–33.0)
Number of patients in clinic	412.8 (408.6–417.0)	500.3 (492.6–508.0)

Data are means (95% CI).

Table 2 —

Selected patient characteristics by propensity score quintile

	No PR	PR
Group 1
n	4,900	420
Sex (% male)	46.1 (44.7–47.5)	44.8 (40.0–49.5)
Age (years)	66.53 (66.13–66.93)	67.3 (66.0–68.7)
Wound area (mm²)	189.79 (158.14–221.43)	153.04 (105.82–200.27)
Wound duration (months)	7.00 (6.44–7.55)	6.02 (4.92–7.13)
Wound grade	2.01 (1.98–2.04)	2.04 (1.94–2.13)
Wound volume (mm³)	1,069.53 (752.44–1,386.62)	825.37 (515.41–1,135.33)
Insurance (%)	76.37 (75.18–77.56)	74.3% (70.1–78.5)
Clinic age (Months)	39.52 (38.71–40.33)	38.4 (35.6–41.3)
Number of patients in clinic	321.2 (313.6–328.8)	332.83 (305.68–359.98)
Group 2
n	4,517	803
Sex (% male)	52.4 (51.0–53.9)	49.9 (46.5–53.4)
Age (years)	64.5 (64.1–64.9)	64.7 (63.7–65.7)
Wound area (mm²)	237.61 (208.97–266.25)	212.48 (184.14–240.81)
Wound duration (months)	7.94 (7.35–8.54)	8.39 (6.74–10.03)
Wound grade	2.36 (2.34–2.39)	2.39 (2.33–2.46)
Wound volume (mm³)	987.66 (828.07–1,147.24)	1,019.95 (827.92–1,211.97)
Insurance (%)	81.25 (80.10–82.39)	80.20 (77.43–82.96)
Clinic age (months)	39.63 (38.82–40.44)	40.78 (38.79–42.77)
Number of patients in clinic	372.6 (364.2–380.9)	379.87 (359.14–400.59)
Group 3
n	4,141	1,178
Sex (% male)	56.3 (54.8–57.8)	56.4 (53.5–59.2)
Age (years)	63.7 (63.3–64.1)	64.2 (63.5–64.9)
Wound area (mm²)	523.32 (487.18–559.46)	489.39 (441.30–537.47)
Wound duration (months)	9.43 (8.55–10.31)	9.13 (7.63–10.64)
Wound grade	2.63 (2.59–2.66)	2.63 (2.57–2.69)
Wound volume (mm³)	3,062.8 (2,676.4–3,449.3)	4,274.31 (3,220.00–5,328.6)
Insurance (%)	83.7 (82.5–84.8)	83.2 (81.1–85.3)
Clinic age (months)	38.6 (37.8–39.4)	39.54 (37.97–41.11)
Number of patients in clinic	413.8 (404.7–422.8)	417.83 (400.58–435.08)
Group 4
n	3,765	1,555
Sex (% male)	58.8 (57.2–60.4)	59.7 (57.2–62.1)
Age (years)	62.5 (62.0–62.9)	61.6 (61.0–62.2)
Wound area (mm²)	1,376.8 (1,272.2–1,481.3)	1,164.14 (1,055.74–1,272.54)
Wound duration (months)	10.19 (9.36–11.02)	10.12 (8.93–11.32)
Wound grade	2.83 (2.80–2.87)	2.80 (2.76–2.85)
Wound volume (mm³)	11,475.3 (9,797.1–13,153.4)	15,336.0 (11,384.8–19,287.1)
Insurance (%)	86.6 (85.5–87.7)	86.4 (84.7–88.1)
Clinic age (months)	36.3 (35.5–37.1)	37.4 (36.1–38.8)
Number of patients in clinic	481.3 (471.7–491.0)	489.6 (474.4–504.7)
Group 5
n	3,024	2,296
Sex (% male)	57.9 (56.1–59.7)	59.3 (57.3–61.3)
Age (years)	62.7 (62.2–63.2)	62.1 (61.6–62.7)
Wound area (mm²)	1,820.7 (1,574.3–2,067.0)	1,542.0 (1,367.6–1,716.4)
Wound duration (months)	12.47 (11.37–13.56)	11.52 (10.33–12.70)
Wound grade	2.70 (2.66–2.74)	2.84 (2.79–2.88)
Wound volume (mm³)	25,017.8 (13,457.2–36,578.3)	22,805.5 (17,360.3–28,250.8)
Insurance (%)	86.4 (85.2–87.6)	88.5 (87.2–89.9)
Clinic age (months)	24.2 (23.5–25.0)	20.8 (20.1–21.5)
Number of patients in clinic	534.7 (523.2–546.3)	622.6 (611.0–634.1)

Data are means (95% CI).

Table 3 —

Proportion of wounds healed by PR status; relative risk of healing with PR and risk difference of healing with PR by quintile

Group	No PR: proportion healed by 32 weeks	PR: proportion healed by 32 weeks	Relative risk of healing with PR
1	46.6 (45.2–48.0)	51.9 (47.1–56.7)	1.14 (1.03–1.27)
2	46.6 (45.1–48.0)	55.0 (51.6–58.5)	1.24 (1.16–1.34)
3	40.4 (38.9–41.9)	49.8 (47.0–52.7)	1.29 (1.20–1.38)
4	35.2 (33.7–36.7)	49.1 (46.6–51.6)	1.43 (1.33–1.52)
5	31.6 (30.0–33.3)	48.5 (46.5–50.6)	1.59 (1.49–1.70)
Overall	41.0 (40.3–41.7)	50.0 (48.7–51.2)	1.38 (1.33–1.42)