Effect of Metformin on Glucagon-Like Peptide 1 (GLP-1) and Leptin Levels in Obese Nondiabetic Subjects
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Figures
- Figure 1 —
Effects of metformin on GLP-1(7–36)amide/(7–37) levels. GLP-1(7–36)amide/(7–37) levels before the beginning of the clamp (pre), immediately before the oral glucose load (0), and 30, 60, and 90 min after the oral glucose load on day 0 (□) and on day 15 (▪). A, active treatment group; B, control group. Data are expressed as means ± SD. *P < 0.05 vs. baseline (time 0); §P < 0.05 vs. before treatment (day 0).
- Figure 2 —
Effects of metformin on GLP-1(7–36)amide degradation in vitro shown by GLP-1(7–36)amide concentrations (% variation from time 0) after a 30-min incubation with metformin in pooled sera from human volunteers (A) and in a buffer solution containing DPP-IV (B), with added 110 pmol/l GLP-1(7–36)amide. Data are expressed as means ± SD. *P < 0.05 vs. control using Student’s unpaired t test and ANOVA.
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