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Epidemiology/Health Services/Psychosocial Research

Heterogeneity in the Relationship Between Ethnicity, BMI, and Fasting Insulin

  1. Latha P. Palaniappan, MD, MS,
  2. Mercedes R. Carnethon, PHD and
  3. Stephen P. Fortmann, MD
  1. From the Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, Stanford, California
    Diabetes Care 2002 Aug; 25(8): 1351-1357. https://doi.org/10.2337/diacare.25.8.1351
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    Abstract

    OBJECTIVE—To determine whether the association of BMI and fasting insulin is modified by ethnicity.

    RESEARCH DESIGN AND METHODS—Non-Hispanic black (black), non-Hispanic white (white), and Mexican-American men and women aged 20–80 years from the Third National Health and Nutrition Examination Survey (1988–1994) were included in this study. Linear regression models with an interaction term were used to test whether ethnicity modified the association between BMI and fasting insulin.

    RESULTS—Fasting insulin was 19, 26, 20, and 19% higher in black women than white women with BMI levels of <22, 22–24, 25–27, and 28–30 kg/m2, respectively. These differences between black and white women converged at BMI levels >30 kg/m2. Mexican-American women had fasting insulin levels that were 17, 22, 20, and 16% higher than those of white women at BMI levels of 25–27, 28–30, 31–33, and >34 kg/m2, respectively, but were not different in individuals with BMI levels <25 kg/m2. Adjusting for established risk factors did not attenuate these associations in women. Differences in fasting insulin among men were not as apparent.

    CONCLUSIONS—These findings suggest that the effect of obesity on insulin sensitivity is different for Americans in ethnic minorities. In black subjects, fasting insulin is higher at lean weight when compared with white and Mexican-American subjects. In Mexican-American subjects, fasting insulin is higher in overweight individuals when compared with white and black subjects. These findings are more pronounced in women than in men. This result reinforces the importance of designing prevention programs that are tailored to meet the needs of specific populations. Investigation of possible explanations for these differences seems warranted.

    • NHANES, National Health and Nutrition Examination Survey

    Footnotes

    • Address correspondence and reprint requests to Latha Palaniappan, Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, 1000 Welch Rd., Palo Alto, CA 94304-1825. E-mail: lathap{at}stanford.edu.

      Received for publication 6 December 2001 and accepted in revised form 9 May 2002.

      A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

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    Heterogeneity in the Relationship Between Ethnicity, BMI, and Fasting Insulin
    Latha P. Palaniappan, Mercedes R. Carnethon, Stephen P. Fortmann
    Diabetes Care Aug 2002, 25 (8) 1351-1357; DOI: 10.2337/diacare.25.8.1351

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    Heterogeneity in the Relationship Between Ethnicity, BMI, and Fasting Insulin
    Latha P. Palaniappan, Mercedes R. Carnethon, Stephen P. Fortmann
    Diabetes Care Aug 2002, 25 (8) 1351-1357; DOI: 10.2337/diacare.25.8.1351
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