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Clinical Care/Education/Nutrition

Effect of Wheat Bran on Glycemic Control and Risk Factors for Cardiovascular Disease in Type 2 Diabetes

  1. David J. A. Jenkins, MD1234,
  2. Cyril W. C. Kendall, PHD13,
  3. Livia S. A. Augustin, MSC13,
  4. Margaret C. Martini, PHD5,
  5. Mette Axelsen, PHD6,
  6. Dorothea Faulkner, RD1,
  7. Edward Vidgen, BSC13,
  8. Tina Parker, RD1,
  9. Herb Lau, MD78,
  10. Philip W. Connelly, PHD2910,
  11. Jerome Teitel, MD78,
  12. William Singer, MD2,
  13. Arthur C. Vandenbroucke, PHD710,
  14. Lawrence A. Leiter, MD1234 and
  15. Robert G. Josse, MD1234
  1. 1Clinical Nutrition and Risk Factor Modification Center, St. Michael’s Hospital, Toronto, Ontario, Canada
  2. 2Department of Medicine, Division of Endocrinology and Metabolism, St. Michael’s Hospital, Toronto, Ontario, Canada
  3. 3Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
  4. 4Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
  5. 5Kraft Foods, Glenview, Illinois
  6. 6Lundberg Laboratory for Diabetic Research, Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
  7. 7Department of Laboratory Medicine, Division of Clinical Biochemistry, St. Michael’s Hospital, Toronto, Ontario, Canada
  8. 8Department of Hematology, St. Michael’s Hospital, Toronto, Ontario, Canada
  9. 9Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
  10. 10Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 2002 Sep; 25(9): 1522-1528. https://doi.org/10.2337/diacare.25.9.1522
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    Abstract

    OBJECTIVE—Cohort studies indicate that cereal fiber reduces the risk of diabetes and coronary heart disease (CHD). Therefore, we assessed the effect of wheat bran on glycemic control and CHD risk factors in type 2 diabetes.

    RESEARCH DESIGN AND METHODS—A total of 23 subjects with type 2 diabetes (16 men and 7 postmenopausal women) completed two 3-month phases of a randomized crossover study. In the test phase, bread and breakfast cereals were provided as products high in cereal fiber (19 g/day additional cereal fiber). In the control phase, supplements were low in fiber (4 g/day additional cereal fiber).

    RESULTS—Between the test and control treatments, no differences were seen in body weight, fasting blood glucose, HbA1c, serum lipids, apolipoproteins, blood pressure, serum uric acid, clotting factors, homocysteine, C-reactive protein, magnesium, calcium, iron, or ferritin. LDL oxidation in the test phase was higher than that seen in the control phase (12.1 ± 5.4%, P < 0.034). Of the subjects originally recruited, more dropped out of the study for health and food preference reasons from the control phase (16 subjects) than the test phase (11 subjects).

    CONCLUSIONS—High-fiber cereal foods did not improve conventional markers of glycemic control or risk factors for CHD in type 2 diabetes over 3 months. Possibly longer studies are required to demonstrate the benefits of cereal fiber. Alternatively, cereal fiber in the diet may be a marker for another component of whole grains that imparts health advantages or a healthy lifestyle.

    • CHD, coronary heart disease
    • NCEP, National Cholesterol Education Program

    Footnotes

    • Address correspondence and reprint requests to David J. A. Jenkins, Clinical Nutrition and Risk Factor Modification Center, St. Michael’s Hospital, 61 Queen St. East, Toronto, Ontario, Canada, M5C 2T2. E-mail: cyril.kendall{at}utoronto.ca.

      Received for publication 12 April 2002 and accepted in revised form 28 May 2002.

      A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

      See accompanying editorial on p. 1652.

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    Effect of Wheat Bran on Glycemic Control and Risk Factors for Cardiovascular Disease in Type 2 Diabetes
    David J. A. Jenkins, Cyril W. C. Kendall, Livia S. A. Augustin, Margaret C. Martini, Mette Axelsen, Dorothea Faulkner, Edward Vidgen, Tina Parker, Herb Lau, Philip W. Connelly, Jerome Teitel, William Singer, Arthur C. Vandenbroucke, Lawrence A. Leiter, Robert G. Josse
    Diabetes Care Sep 2002, 25 (9) 1522-1528; DOI: 10.2337/diacare.25.9.1522

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    Effect of Wheat Bran on Glycemic Control and Risk Factors for Cardiovascular Disease in Type 2 Diabetes
    David J. A. Jenkins, Cyril W. C. Kendall, Livia S. A. Augustin, Margaret C. Martini, Mette Axelsen, Dorothea Faulkner, Edward Vidgen, Tina Parker, Herb Lau, Philip W. Connelly, Jerome Teitel, William Singer, Arthur C. Vandenbroucke, Lawrence A. Leiter, Robert G. Josse
    Diabetes Care Sep 2002, 25 (9) 1522-1528; DOI: 10.2337/diacare.25.9.1522
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