Prevalence and Concomitants of Glucose Intolerance in European Obese Children and Adolescents
Article Figures & Tables
Figures
- Figure 1—
BP at different ages in boys (A and B) and girls (C and D) in 710 obese children. The solid line represents the age- and sex-related 95th percentile of BP (18).
- Figure 2—
Pattern of HOMAIR (A), systolic BP (B), triglycerides (C), and HDL cholesterol (D) during the different pubertal stages in 710 obese children. Results are expressed as the means ± SE adjusted for SDS-BMI and age.
Tables
- Table 1—
Demographic, clinical, and biochemical features of a cohort of 710 obese children and adolescents
Variable Boys Girls Whole group n 345 365 710 Age (years) 14 (6–18) 14 (7–18) 14 (6–18) Height (cm) 161.0 ± 12.0* 156.1 ± 10.6 158.8 ± 11.5 Weight (kg) 93.5 ± 25.7* 85.6 ± 20.3 88.9 ± 23.6 SDS-BMI 4.1 ± 0.7* 3.6 ± 0.6 3.8 ± 0.7 BMI (kg/m2) 35.2 ± 6.1 34.8 ± 5.8 35.0 ± 6.0 Waist (cm) 104.1 ± 5.3† 95.5 ± 7.6 98.3 ± 7.9 Duration of obesity (year) 7.1 ± 3.6 6.7 ± 3.6 6.8 ± 3.5 Obesity in family (%) 58 63 61 Diabetes in family (%) 53 55 54 Birth weight (g) 3423 ± 511.6 3411 ± 571.3 3417 ± 542.3 LDL cholesterol (mmol/l) 2.7 ± 0.8 2.6 ± 0.7 2.6 ± 0.8 HDL cholesterol (mmol/l) 1.2 ± 0.3 1.2 ± 0.3 1.2 ± 0.3 Triglycerides (mmol/l) 1.2 ± 0.3 1.2 ± 0.3 1.2 ± 0.3 Uric acid (μmol/l) 382.6 ± 116* 347 ± 102 364.2 ± 110.6 Fibrinogen (mg/dl) 377.7 ± 73.4† 392.3 ± 77.9 385.5 ± 76.1 CRP (mg/dl) 0.5 ± 0.7 0.5 ± 0.5 0.5 ± 0.6 Systolic BP (mmHg) 128 ± 14* 124 ± 14 126 ± 14 Diastolic BP (mmHg) 77 ± 9 77 ± 10 76 ± 10 - Table 3—
Relationship between obesity, postload glucose, and insulin resistance with cardiovascular risk factors in 710 obese children and adolescents
Variable Regression coefficient P value SDS-BMI CRP 0.207 0.000 Fibrinogen 0.179 0.000 HDL cholesterol −0.190 0.000 Triglycerides 0.126 0.001 Systolic BP 0.167 0.000 Diastolic BP 0.120 0.002 HOMAIR 0.114 0.003 ΔI30/ΔG30 0.091 0.010 Birth weight 0.098 0.027 Uric acid 0.260 0.000 HOMAIR Triglycerides 0.221 0.000 HDL cholesterol −0.120 0.001 Systolic BP 0.109 0.005 Diastolic BP 0.157 0.000 2-h BG 0.141 0.001 ΔI30/ΔG30 0.178 0.000 SDS-BMI 0.114 0.003 Uric acid 0.089 0.029 2-h BG ΔI30/ΔG30 −0.159 0.000 HOMAIR 0.141 0.001 Diastolic BP 0.097 0.003 Triglycerides 0.081 0.050 -
ΔI30/ΔG30, insulinogenic index.
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- Table 4—
Variables independently associated, in an age- and sex-adjusted stepwise multiple linear regression analysis, with the dependent variables 2-h blood glucose and SDS-BMI in 710 obese children and adolescents
Dependent variable Independent variable β coefficient P value 2-h BG ΔI30/ΔG30 −0.186 0.000 HOMAIR 0.158 0.000 Diastolic BP 0.094 0.018 SDS-BMI Fibrinogen 0.141 0.003 CRP 0.143 0.000 Uric acid 0.168 0.000 HDL cholesterol −0.171 0.000 Systolic BP 0.118 0.009 ΔI30/ΔG30 0.135 0.002 Birth weight 0.102 0.002 -
ΔI30/ΔG30, insulinogenic index.
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