Influence of Alcohol Intake and Aldehyde Dehydrogenase 2 Phenotype on Peripheral Neuropathy of Diabetes
- Yoshihiko Suzuki, MD1,
- Matsuo Taniyama, MD2,
- Taniyama Muramatsu, MD3,
- Shigeo Ohta, PHD4,
- Yoshito Atsumi, MD1 and
- Kempei Matsuoka, MD1
- 1Saiseikai Central Hospital, Tokyo, Japan
- 2Fujigaoka Hospital, Showa University, Kanagawa, Japan
- 3Department of Neuropsychiatry, Keio University, Tokyo, Japan
- 4Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School, Nippon, Japan
In Asians, the differences of alcohol tolerance are mainly determined by a polymorphism of aldehyde dehydrogenase 2 (ALDH2), which metabolizes acetaldehyde produced from ethanol into acetate (1). To examine whether the inactive ALDH2 influences the peripheral neuropathy in diabetes, 194 Japanese patients with type 2 diabetes (135 men and 58 women, aged 59.1 ± 11.7 years) were divided by ALDH2 phenotype and alcohol consumption and then the correlation of NCV (nerve conduction velocity in …
In this Issue
January 2003, 26(1)
Influence of Alcohol Intake and Aldehyde Dehydrogenase 2 Phenotype on Peripheral Neuropathy of Diabetes
