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Epidemiology/Health Services/Psychosocial Research

Costs Associated With the Primary Prevention of Type 2 Diabetes Mellitus in the Diabetes Prevention Program

  1. The Diabetes Prevention Program Research Group*
  1. From the Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, Rockville, Maryland
    Diabetes Care 2003 Jan; 26(1): 36-47. https://doi.org/10.2337/diacare.26.1.36
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    Article Figures & Tables

    Tables

    • Table A1—

      Unit costs used for calculating costs of DPP by type of cost

      ItemsUnitCost (median/mean, $)Sources
      Direct medical costs
       DPP personnel
        LCM1 h23.55DPP
        MCM1 h25.24DPP
        Exercise trainer1 h26.02DPP
        Dietitian1 h26.21DPP
        Medical assistant1 h18.14DPP
        Secretary1 h19.54DPP
       Materials
        Educational and training material
      Lifestyle1 set8.85DPP
      Metformin1 set0.08DPP
      Placebo1 set2.26DPP
       Lab tests and procedures
        OGTT117.229
        Exercise tests (CVD stress)1114.009
        Venipuncture13.009
        Serum creatinine16.849
        Urine creatinine16.929
        Hemoglobin/hematocrit17.919
       Medication
        Metformin1 tablet1.1010
        Prescription medications1 year/person407.0011
       Bundled medical services
        Hospital days*12,353.0012,13
        Emergency room visits†1167.0013
        Urgent care visits191.0013
        Outpatient visits151.0013
        Calls to providers120.0013
      Direct nonmedical costs
       Participant time
        Travel time1 h8.0014
        People who dislike exercise1 h8.0014
        People who are neutral about exercise1 h4.0014
        Shopping and cooking1 h4.0014
       Services
        Exercise classes1 week16.6015
        Health club3 years2,305.0016
        Personal trainer1 h34.0017
        Commercial weight loss classes1 month46.0016
       Fitness equipment
        Exercise shoes1 pair73.2716
        Bicycle1430.4016
        Exercise videos115.0216
        Free weights239.0618
        Golf clubs1 set390.6118
        Home gym1683.5716
        Stationary bicycle1548.8016
        Step1 system78.1218
        Treadmill11,100.0016
       Food equipment
        Air popper125.3919
        Blender139.7016
        Cookbooks125.3920
        Food scale124.4121
        Freezer1449.5416
        Microwave1155.0416
        Mixer1132.4616
        Steamer131.0116
        Wok1 set206.1016
       Food costs
        Food at home1 year1,633.0022
        Food away from home1 year1,430.0022
       Transportation costs1 mile0.3523
       Indirect costs
        Time lost from doing usual activity due to morbidity or mortality1 day108.0014
      • *

        ↵* Cost of a hospital day based on facility charge of $2,242 (Health Care Utilization Project) and a physician fee of $111.

      • †

        ↵† Cost of an emergency room visit based on the facility charge of $102 (Health Care Financing Administration, personal communication with Mr. Jerry Riley) and a physician fee of $51 (HealthCare Consultants of America). LCM, Lifestyle Case Manager; MCM, Medication Case Manager.

    • Table 1—

      Per capita direct medical costs of the placebo intervention by year

      ItemProviderUnitsSubjects (%)Time (h)Unit cost ($)Total cost ($)
      Year 1
       1st visit counselingMCM11000.5025.2413
       1st visit materials
        On Your Way to Fitness11001.001
        Dietary Guidelines for Americans1751.161
       3-month visit counselingMCM11000.2525.246
       3-month visit dietDietitian1120.6326.122
       Phone callsMCM1100.1625.240
       Reminder phone callsSecretary21000.0819.543
       Overhead (69% of personnel)17
       Total cost (year 1)43
      Year 2
       Annual visitMCM11000.3325.248
       Phone callsMCM1100.1625.240
       Reminder phone callsSecretary11000.0819.542
       Overhead (69% of personnel)7
       Total cost (year 2)18
      Year 3
       Annual visitMCM11000.3325.248
       Phone callsMCM1100.1625.240
       Reminder phone callsSecretary11000.0819.542
       Overhead (69% of personnel)7
       Total cost (year 3)18
      Total cost (years 1–3)79
      • MCM, Medication Case Manager.

    • Table 2—

      Per capita direct medical costs of the metformin intervention by year

      ItemProviderUnitsSubjects (%)Time (h)Unit cost ($)Total cost ($)
      Year 1
       Standard lifestyle recommendation (see Table 1 year 1 for details)43
       Baseline history and physical examPhysician110091.0091
       Baseline labs
        Venipuncture11003.003
        Serum creatinine11006.847
        Hemoglobin/hematocrit11007.918
        Urine creatinine10.36.920
       Metformin fact-sheet11000.080
       Metformin
        0 tablet dose091.100
        1 tablet dose365151.1060
        2 tablet dose730761.10610
       Follow-up visitsMCM3.461000.3325.2429
      MA3.46620.3318.1413
       Dose-titration/restart visitsMCM1.391000.3325.2412
       Outbound phone callsMCM3250.1625.243
       Inbound phone callsMCM2300.1625.243
       Reminder phone callsSecretary5.851000.0819.5410
       Tool box17
       Overhead (69% of personnel)110
       Total cost (year 1)1,019
      Year 2
       Standard lifestyle recommendation (see Table 1 year 2 for details)18
       Lab monitoring
        Venipuncture1843.003
        Serum creatinine1846.846
        Hemoglobin/hematocrit1847.917
        Urine creatinine10.46.920
       Metformin
        0 tablet dose0161.100
        1 tablet dose365141.1056
        2 tablet dose730701.10562
       Follow-up visitsMCM3.971000.3325.2433
       MA3.97620.3318.1415
       Dose-titration/restart visitsMCM0.071000.3325.241
       Outbound phone callsMCM3250.1625.243
       Inbound phone callsMCM2300.1625.243
       Reminder phone callsSecretary4.041000.0819.547
       Tool box17
       Overhead (69% of personnel)42
       Total cost (year 2)772
      Year 3
       Standard lifestyle recommendation (see Table year 3 for details)18
       Lab monitoring
        Venipuncture1803.002
        Serum creatinine1806.845
        Hemoglobin/hematocrit1807.916
        Urine creatinine10.46.920
       Metformin
        0 tablet dose0201.100
        1 tablet dose365121.1048
        2 tablet dose730681.10546
       Follow-up visitsMCM3.971000.3325.2433
       MA3.97620.3318.1415
       Dose-titration/restart visitsMCM0.071000.3325.241
       Outbound phone callsMCM3250.1625.243
       Inbound phone callsMCM2300.1625.243
       Reminder phone callsSecretary4.041000.0819.547
       Tool box22
       Overhead (69% of personnel)42
       Total cost (year 3)751
      Total cost (years 1–3)2,542
      • MA, Medical Assistant; MCM, Medication Case Manager.

    • Table 3—

      Per capita direct medical costs of the lifestyle intervention by year

      ItemProviderUnitsSubjects (%)Time (h)Unit cost ($)Total cost ($)
      Year 1
       Baseline history and physical examPhysician110091.0091
       Exercise test119114.0022
       Core curriculumLCM161001.0023.55377
       Materials11008.859
       Supervised activity sessions
       LCM4.27601.0023.5560
       Trainer4.27401.0026.0244
       Lifestyle group sessionsLCM0.361001.2523.5511
       In-person visitsLCM7.651000.5823.55105
       Phone callsLCM2.321000.2523.5514
       Reminder phone callsSecretary29.411000.0819.5448
       Tool box102
       Overhead (69% of personnel)517
       Total cost (year 1)1,399
      Year 2
       Supervised activity sessions
       LCM4.27601.0023.5560
       Trainer4.27401.0026.0244
       Lifestyle group sessionsLCM0.721001.2523.5521
       In-person visitsLCM12.331000.5823.55169
       Phone callsLCM2.661000.2523.5516
       Reminder phone callsSecretary17.451000.0819.5428
       Tool box105
       Overhead (69% of personnel)234
       Total cost (year 2)679
      Year 3
       Supervised activity sessions
       LCM4.27601.0023.5560
       Trainer4.27401.0026.0244
       Lifestyle group sessionsLCM0.721001.2523.5521
       In-person visitsLCM12.331000.5823.55169
       Phone callsLCM2.661000.2523.5516
       Reminder phone callsSecretary17.451000.0819.5428
       Tool box128
       Overhead (69% of personnel)234
       Total cost (year 3)702
      Total cost (Years 1–3)2,780
      • LCM, Lifestyle Case Manager.

    • Table 4—

      Per capita direct medical costs of care outside the DPP by intervention group, years 1–3

      PlaceboPlacebo costsMetforminMetformin costsLifestyleLifestyle costsMetformin vs. placebo ($)Lifestyle vs. placebo ($)
      Hospital days0.811,9060.721,6940.721,694−212−212
      Emergency room visits0.661100.651090.74124−213
      Urgent care visits1.381261.321201.21110−5−15
      Outpatient visits12.9466013.2667611.6359316−67
      Calls to providers10.3420711.1622310.0820216−5
      Prescription medications4.922,0024.711,9174.551,856−85−147
      Total (years 1–3)5,0114,7394,579−272−432
    • Table 5—

      Per capita direct nonmedical costs by intervention group, years 1–3

      PlaceboPlacebo costs ($)MetforminMetformin costs ($)LifestyleLifestyle costs ($)Metformin vs. placebo ($)Lifestyle vs. placebo ($)
      Participant time
       Visits24.17 h19339.62 h317135.67 h1,085124892
       Adjusted exercise*163.35 h728164.83 h731150.80 h7043−24
       Shopping and cooking1120.58 h4,4821075.74 h4,3031062.78 h4,251−179−231
       Total5,4045,3506,040−52637
      Services
       Exercise classes16%20714%18121%272−2565
       Health club19%21919%21827%311−192
       Personal trainer4%74%75%802
       Commercial weight loss classes12%9913%1076%508−49
       Total532514642−18110
      Fitness equipment
       Bicycle†13%2811%2417%37−49
       Exercise videos29%425%437%601
       Free weights24%921%835%14−14
       Golf clubs†5%104%85%10−20
       Home gym†5%174%145%17−30
       Stationary bicycle†10%2810%2713%3608
       Step4%34%37%502
       Treadmill†12%6611%6118%99−533
       Total165148223−1758
      Food equipment
       Air popper7%24%19%2−11
       Blender21%821%821%800
       Cookbooks42%1142%1151%1302
       Food scale11%312%326%604
       Freezer†7%167%167%1600
       Microwave†15%1215%1215%1200
       Mixer†11%710%78%5−1−2
       Steamer14%415%521%702
       Wok†8%88%810%1002
       Total717079−19
      Shoes3 pairs2203 pairs2206 pairs4390220
      Food costs
       Food at home4,9954,9875,002−77
       Food away from home4,2294,2394,15010−79
       Total9,2239,2269,1523−71
      Transportation costs224.4 miles79440.6 miles1541606.2 miles56276484
      Grand total15,69215,68317,137−91,445
      • *

        ↵* Leisure-time physical activity was valued according to whether participants “disliked,” were “neutral,” or “liked” leisure-time physical activity.

      • †

        ↵† We assumed that durable equipment initially valued at >$100 (see appendix) retained 50% of its original purchase price after 3 years. Percent value stated in rounded numbers.

    • Table 6—

      Indirect costs by intervention group, years 1–3

      Placebo (days)Placebo costs ($)Metformin (days)Metformin costs ($)Lifestyle (days)Lifestyle costs ($)Metformin vs. placebo ($)Lifestyle vs. placebo ($)
      Morbidity21.312,30123.312,51721.232,293216−1
      Mortality2.803022.933161.2713714−165
      Total2,6042,8342,430230−174
    • Table 7—

      Per capita differences in costs of the metformin and lifestyle interventions relative to the placebo intervention (year 2000, U.S. dollars) over 3 years in DPP

      Metformin vs. placebo ($)Lifestyle vs. placebo ($)
      Direct medical costs
       Intervention2,4632,701
       Care outside DPP−272−432
      Total2,1912,269
      Direct nonmedical costs−91,445
      Indirect costs230−174
      Total cost
       Health system perspective2,1912,269
       Societal perspective2,4123,540
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    Diabetes Care: 26 (1)

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    Costs Associated With the Primary Prevention of Type 2 Diabetes Mellitus in the Diabetes Prevention Program
    The Diabetes Prevention Program Research Group
    Diabetes Care Jan 2003, 26 (1) 36-47; DOI: 10.2337/diacare.26.1.36

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    The Diabetes Prevention Program Research Group
    Diabetes Care Jan 2003, 26 (1) 36-47; DOI: 10.2337/diacare.26.1.36
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