French Multicentric Survey of Outcome of Pregnancy in Women With Pregestational Diabetes

Clinical Care/Education/Nutrition

Address correspondence and reprint requests to Jacques Lepercq, MD, Service de Gynécologie-Obstétrique, Hôpital Cochin-Saint Vincent de Paul, 82, Avenue Denfert-Rochereau, 75674 Paris cedex 14, France. E-mail: j.lepercq{at}svp.ap-hop-paris.fr

Diabetes Care 2003 Nov; 26(11): 2990-2993. https://doi.org/10.2337/diacare.26.11.2990

Article Figures & Tables

Table 1—
Maternal data in 435 pregnancies in women with type 1 and type 2 diabetes
Parameters Type 1 diabetes Type 2 diabetes
n 289 146
Retinopathy 99 (34.3) 4 (2.7)
Nephropathy 34 (11.8) 7 (4.8)
First trimester HbA_1c >8% 88 (30.4) 32 (21.9)

Data are n (%).

Table 2—

Perinatal mortality and major congenital malformations in 435 pregnancies in women with type 1 and type 2 diabetes

Parameters	Type 1 diabetes	Type 2 diabetes
n	289	146
Perinatal mortality	19 (6.6)	6 (4.1)
Stillbirth 22–27 weeks of gestation	8 (2.8)	2 (1.4)
Stillbirth >27 weeks of gestation	4 (1.4)	1 (0.7)
Neonatal mortality	1 (0.3)	3 (2.1)
Congenital malformations	13 (4.5)	5 (3.4)

Table 3—

Associated factors with preterm delivery

Parameters	Univariate analysis	Multivariate analysis
Parameters		P	P	OR (95% CI)
First trimester HbA_1c >8%	0.0004	0.002	2.2 (1.4–3.7)
Pre-existing retinopathy	0.03	0.5	1.2 (0.7–2.2)
Pre-existing nephropathy	0.0001	0.005	3.5 (1.5–8.6)
Deterioration of retinopathy	0.03	0.7	0.9 (0.4–1.9)
Gestational hypertension/pre-eclampsia	<0.0001	<0.0001	6.1 (3.4–11.0)

Table 4—
Association among preconception care, prepregnancy control, and pregnancy outcome in 289 women with type 1 diabetes
Parameters Preconception care
P
Yes No
Total 140 (48.5) 149 (51.5)
First trimester HbA_1c >8% 6 (4.3) 82 (55.0) <0.0001
Perinatal mortality 1 (0.7) 12 (8.1) <0.005
Congenital malformation 1 (0.7) 12 (8.1) <0.005

Data are n (%).
Table 5—
Association among preconception care, prepregnancy control, and pregnancy outcome in 146 women with type 2 diabetes
Parameters Preconception care
P
Yes No
Total 35 (24.0) 111 (76.0)
First trimester HbA_1c >8% 1 (2.9) 31 (27.9) <0.001
Perinatal mortality 2 (5.7) 4 (3.6) NS
Congenital malformation 1 (2.9) 4 (3.6) NS

Data are n (%). NS, not significant.

November 2003, 26(11)