Exercise Training, Without Weight Loss, Increases Insulin Sensitivity and Postheparin Plasma Lipase Activity in Previously Sedentary Adults

Clinical Care/Education/Nutrition

¹Department of Medicine (Division of Endocrinology and Metabolism), University of Florida, Gainesville, Florida
²Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida
³General Clinical Research Center, University of Florida, Gainesville, Florida
⁴Department of Biostatistics, University of Florida, Gainesville, Florida
⁵Department of Medicine (Division of Endocrinology, Metabolism and Diabetes), University of Colorado Health Sciences Center, Denver, Colorado
⁶Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida

Diabetes Care 2003 Mar; 26(3): 557-562. https://doi.org/10.2337/diacare.26.3.557

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Figure 1—
Relative percentages of LPL (dark bars) and HL (light bars) comprising the total PHPL activity before and after 6 months of exercise training in 18 sedentary adults. The LPL:HL ratio increased significantly after training (0.75 ± 0.60 vs. 1.15 ± 0.53, P = 0.02).

Table 1—

Metabolic parameters before and after training in previously sedentary adults (n = 18)

Variable	Baseline value	6-Month value	Change
S_I (μU · ml⁻¹ · min⁻¹)	2.54 ± 2.74	4.41 ± 3.30	1.87 ± 2.45*
LPL nEq FFA · ml⁻¹ · h⁻¹	1,890 ± 1,380	4,926 ± 1,858	3,035 ± 2,192*
HL nEq FFA · ml⁻¹ · h⁻¹	3,326 ± 1,605	4,636 ± 1,636	1,310 ± 1,140*
K₂ (%/min)	3.37 ± 0.90	3.25 ± 0.90	−0.05 ± 0.84
TG (mg/dl)	123.3 ± 67.2	118.2 ± 64.7	−5.1 ± 22.9
Total cholesterol (mg/dl)	196.3 ± 41.2	186.5 ± 34.4	−9.8 ± 23.3
LDL cholesterol (mg/dl)	117.7 ± 31.9	110.2 ± 28.2	−7.4 ± 19.2
HDL cholesterol (mg/dl)	54.4 ± 8.8	52.6 ± 8.7	−1.8 ± 6.6
Total-to-HDL ratio	3.73 ± 1.00	3.72 ± 1.10	−0.02 ± 0.29