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Clinical Care/Education/Nutrition

Type 2 Diabetes in Asian-Indian Urban Children

  1. Ambady Ramachandran, MD, PHD, DSC, FRCP1,
  2. Chamukuttan Snehalatha, MSC, DSC2,
  3. Kumpatla Satyavani, MSC, MTech2,
  4. Selvaraj Sivasankari, MSC2 and
  5. Viswanathan Vijay, MD, PHD1
  1. 1From the Diabetes Research Centre and M.V. Hospital for Diabetes, WHO Collaborative Centre for Research, Education and Training in Diabetes, Departments of Diabetology, Royapuram, Chennai, India
  2. 2Department of Biochemistry, Royapuram, Chennai, India
    Diabetes Care 2003 Apr; 26(4): 1022-1025. https://doi.org/10.2337/diacare.26.4.1022
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    Abstract

    OBJECTIVE—Due to a background of high prevalence of type 2 diabetes and the increasing rate of obesity occurring in relatively young urban children, we felt the need to look for type 2 diabetes in children.

    RESEARCH DESIGN AND METHODS—A study of cases of type 2 diabetes with age at diagnosis of ≤15 years seen at a diabetes speciality center in Chennai, India, is reported. A total of 18 children (5 boys and 13 girls) aged 9–15 years with insidious onset of diabetes responding to oral antidiabetic agents (ODAs) for periods from 2 months to 12 years were studied. Clinical details, anthropometry, and details of family history of diabetes were elicited. All of them were tested for the presence of anti-GAD65 antibodies and for pancreatic β-cell reserve by measuring serum C-peptide response (radioimmunoassay procedures).

    RESULTS—All children showed a response to ODAs, had good β-cell reserve (≥0.6 pmol/ml on stimulation), and negligible GAD65 antibodies indicating the presence of type 2 diabetes. The children were nonketotic; nine were obese, four had acanthosis nigricans, and one had polycystic ovary syndrome. Positive family history of diabetes was present in all cases.

    CONCLUSIONS—The clinical, immunological, and biochemical profile showed that the children had type 2 diabetes. The profile of type 2 diabetes was similar to that described in children in many other countries. Although less common than type 1 diabetes, type 2 diabetes in children is a condition that needs to be recognized and looked for in Asian-Indians.

    • MODY, maturity-onset diabetes of the young
    • ODA, oral antidiabetic agent

    Type 2 diabetes poses a major health problem globally, especially in many developing countries (1). In urban India, type 2 diabetes is reaching epidemic proportions (2–5). Diabetes develops at a younger age in Indians, i.e., at least a decade or two earlier than in the Western population (4,6). We have reported a high prevalence of maturity-onset diabetes of the young (MODY) in our population (7). Reports from different parts of the world, especially from the U.K. (8–10) and the U.S. (11–13), show an increasing occurrence of type 2 diabetes in children, particularly in the minority populations, including Asians. The American Diabetes Association has highlighted a high prevalence of type 2 diabetes in children in ethnic minority populations such as the American and Canadian Indians, Hispanics, African Americans, Japanese, Pacific Islanders, and Asian and Middle-Eastern populations (14). Obesity has been on the rise in the adolescent age, which might have a causative role for the rising prevalence of diabetes in the young (8–13,15).

    A recent survey in southern India has shown that obesity among adolescent school children was related to decreased physical activity (16). It is likely that with the emerging epidemic of diabetes and obesity, type 2 diabetes could occur in children in India. This report highlights the need to look for type 2 diabetes in children in India.

    RESEARCH DESIGN AND METHODS

    Children with diabetes diagnosed ≤15 years who had features of type 2 diabetes (n = 18) are reported here. They were seen at the Diabetes Research Centre and M.V. Hospital for Diabetes, Madras, India. Among them, three cases were diagnosed within the last 3 months. The other 15 cases were diagnosed by us at least 1 year ago and patients had come for follow-up from January to June 2002. All of them satisfied the criteria given below.

    1. Insidious onset of diabetes at age of ≤15 years

    2. Response to treatment with ODAs

    3. Presence of insulin secretory capacity comparable to type 2 diabetes in adults, as indicated by serum C-peptide concentrations (stimulated response ≥ 0.6 pmol/ml)

    4. Lack of evidence of autoimmune process indicated by the absence of circulating GAD65 antibodies.

    Informed consent was obtained from the parents to use the data of the probands and the family members for scientific purposes. The study protocol was also approved by the ethics committee of the Diabetes Research Centre and M.V. Hospital for Diabetes.

    Details of clinical history with emphasis on presence of symptoms were recorded. Blood pressure was measured, the details of dietary habits were noted, and waist-to-hip ratio was calculated. Anthropometric measurements included height, weight, and waist and hip circumferences. For each child, the percentage of body weight for the height was calculated using the table for normal height and weight for Indian children (17). Family history of diabetes was noted. We looked for skin manifestation of acanthosis nigricans. A total of 18 parents without known history of diabetes were invited to undergo a standard oral glucose tolerance test. Among them, diabetes was diagnosed in four fathers and five mothers. All children had measurements of fasting and 2-h postprandial plasma glucose (glucose oxidase-peroxidase method), HbA1c (immunoturbidimetry method; Roche Diagnostics, Mannheim, Germany; normal value <6.1%), fasting total cholesterol, and triglycerides (enzymatic methods; Roche Diagnostics). A total cholesterol value of ≥200 mg/dl (5.2 mmol/l) and a triglyceride value of ≥150 mg/dl (1.7 mmol/l) were considered abnormal.

    GAD65 antibodies were measured in fasting serum by radioimmunoassay procedure using a commercial reagent kit that used I125-labeled human recombinant GAD65 (RSR, Cardiff, U.K.). The performance of the assay had been evaluated using S35-labeled human recombinant GAD65 as a reference method (18), and it was found to have a significant correlation (r = 0.93) with the standard assay (19). It had a sensitivity very similar to the standard assay, at specificities of 97.5 and 99%. The lowest titer detected was 0.02 units/ml. The intra- and interassay coefficient of variations were <10%. The cutoff value (<1.1 unit/ml) for the normal titer was determined earlier by measuring the antibody titer in 105 nondiabetic healthy individuals (20).

    Serum C-peptide in response to a meal stimulus was estimated in all during a review. C-peptide measured at the time of diagnosis could be misleading due to glucotoxicity and/or β-cell suppression by exogenous insulin administration, if any (21). Commercial radioimmunoassay reagents (Diagnostic Products, Los Angeles, CA) were used. The intra-assay coefficient of variation was 5.5% and interassay coefficient of variation was <6.8%, and the lowest detection limit was 0.003 pmol/ml. Stimulated C-peptide value ≥0.6 pmol/ml indicated good β-cell reserve (22). Mean and SDs of the numerical variables are given.

    RESULTS

    Details of 18 children (5 males and 13 females), belonging to 17 families and identified as having type 2 diabetes, are reported. Among them, 15 had been treated with ODAs for durations ranging from 1 to 12 years; the remaining 3 recently diagnosed girls were being treated with ODAs for 2–3 months. All of the children showed good glycemic control with treatment. The clinical details are shown in Table 1. Monotherapy with metformin or sulfonylureas or a combination of both were prescribed. The age at diagnosis was 9–12 years in seven children, 13–14 years in six children, and 15 years in the other five subjects. All children had a positive family history of type 2 diabetes; parental history was present in 16, and the other 2 children had second-degree family history (grandparents with type 2 diabetes).

    At diagnosis, nine children (50%) had ≥120% of ideal body weight and only three children were <100% of ideal body weight. The waist-to-hip ratio was high in 12 of 13 children who had their circumferences measured (normal values males = 0.88, females = 0.80) (Table 1).

    At presentation, five children had polyuria and polydypsia, one had ketonuria, one girl had polycystic ovary syndrome, and three children had pruritis. Acanthosis nigricans was present in four children. Asymptomatic children (n = 9) were tested because of the strong family history of diabetes and/or because of obesity.

    Before reporting to the center, one girl and one boy were being treated with insulin for >1 month and another three girls and one boy were treated with insulin for <10 days. All of them had symptoms suggestive of hypoglycemia, even with minimum doses of insulin, and responded to ODAs.

    The biochemical parameters at the time of registration at the center are shown in Table 2. Isolated hypertriglyceridemia (n = 5), hypercholesterolemia (n = 3), and a combined hyperlipidemia (n = 2) were seen in some children. The C-peptide values ranged from 0.6 to 2.2 pmol/ml with a mean of 1.46 ± 0.4 pmol/ml. Table 2 also shows the fasting and 2-h postprandial plasma glucose values and HbA1c values.

    One 15-year-old girl (subject no. 9) had not attained menarche. One patient was hypertensive and was treated with enalpril. All other children had normal blood pressure. The diets of all study subjects were almost similar, with calories varying from 1,200 to 2,000. They were all consuming the regular Indian diet containing 60–65% of carbohydrate and 20–25% of fat. Physical activity was sedentary in 17 of 18 children; one girl (subject no. 15) previously played tennis regularly.

    CONCLUSIONS

    Type 2 diabetes in children has been reported from developed countries such as the U.K. (8–10), the U.S. (11–13), and Japan (23). Its rising occurrence has been attributed to the increasing rate of obesity in children (24). The susceptibility to the disorder was more common in ethnic minorities such as the Pima Indians in the U.S. (13,14) and Asian-Indians and Arabs in the U.K. (9). The highest prevalence of type 2 diabetes in children has been reported from Japan (23). Childhood obesity has increased enormously in parallel with rapid westernization of lifestyle in Japan. A high prevalence of glucose intolerance was observed in obese Japanese children. Impaired glucose tolerance/impaired fasting glucose and type 2 diabetes were found in 19.2 and 3.9%, respectively, of 280 children who were overweight by ≥30% of the standard weight. They had high insulin resistance that resulted in subsequent diabetes (23).

    The present article highlights the fact that type 2 diabetes in children occurs even in developing countries. In concurrence with the reports from the developed countries (8–14,23,24), obesity, female sex, parental history of type 2 diabetes, and pubertal age appeared to be strongly associated with the disease in Asian children. Unlike in the children with type 1 diabetes who had acute onset of the disease with severe symptoms and ketonuria, lean body weight, and lack of familial aggregation, the type 2 diabetic children showed features similar to classic adult-onset type 2 diabetes. Obesity was present in only half of the probands seen by us. The profile is similar to that observed in adult type 2 diabetes in India—nearly half of type 2 diabetic patients are not obese. Insulin resistance is a common feature even in nonobese Asian-Indian subjects (25).

    Clinical conditions associated with insulin resistance like acanthosis nigricans and polycystic ovary syndrome were common in the young type 2 diabetic patients. A similar profile had been reported by Drake et al. (8) and Ehtisham et al. (9) from the U.K. and also in the reports from the U.S. (14). The mean age at onset of the disease was peripubertal coinciding with the relative insulin resistance occurring during puberty. Strong familial inheritance, presence of obesity, nonautoimmune nature as indicated by the absence of GAD antibodies, and good response to ODAs favored the diagnosis of type 2 diabetes in our study group as well as in the reports from other ethnic groups (8–14,23).

    The longest duration of diabetes in two probands was 12 years, and both were continuing to show good glycemic control with ODAs. In obese children with diabetes, metformin was found to be effective. Sulfonylureas were also effective in other children. The possible presence of the metabolic syndrome and the long duration of diabetes could favor development of vascular complications at a young age in these subjects.

    It is difficult to have a clear cut demarcation of MODY and type 2 diabetes in the young. Although the prevalence of type 2 diabetes in children is not known at present, type 2 diabetes in children is an entity that needs to be recognized and looked for, especially in obese children of diabetic parents in India. Asymptomatic nature may delay the diagnosis in many as it usually does in adult type 2 diabetic subjects.

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    Table 1—

    Clinical characteristics of the study subjects

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    Table 2—

    Anthropometric and biochemical details of the study subjects: basal values

    Acknowledgments

    We thank the secretarial assistance of Karvesseri Vettath Bindhu in preparation of the manuscript.

    Footnotes

    • Address correspondence and reprint requests to Prof. A. Ramachandran, MD, PHD, DSC, FRCP, Director, Diabetes Research Centre and M.V. Hospital for Diabetes, 4 Main Road, Royapuram, Chennai 600 013, India. E-mail: ramachandran{at}vsnl.com.

      Received for publication 13 August 2002 and accepted in revised form 15 January 2003.

      A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    • DIABETES CARE

    References

    1. ↵
      King H, Aubert RE, Herman WH: Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections. Diabetes Care 21:1414–1431, 1998
      OpenUrlAbstract/FREE Full Text
    2. ↵
      Ramachandran A, Snehalatha C, Daisy Dharmaraj, Viswanathan M: Prevalence of glucose intolerance in Asian Indians: urban-rural difference and significance of upper body adiposity. Diabetes Care 15:1348–1355, 1992
      OpenUrlAbstract/FREE Full Text
    3. Ramachandran A, Snehalatha C, Latha E, Vijay V, Viswanathan M: Rising prevalence of NIDDM in urban population in India. Diabetologia 40:232–237, 1997
      OpenUrlCrossRefPubMedWeb of Science
    4. ↵
      Ramachandran A, Snehalatha C, Kapur A, Vijay V, Mohan V, Das AK, Rao PV, Yajnik CS, Prasanna KS, Nair JD: High prevalence of diabetes and impaired glucose tolerance in India-National Urban Diabetes Survey (NUDS). Diabetologia 44:1094–1101, 2001
      OpenUrlCrossRefPubMedWeb of Science
    5. ↵
      Kutty VR, Soman CR, Joseph A, Pisharody R, Vijayakumar K: Type 2 diabetes in southern Kerala: variation in prevalence among geographic divisions within a region. Natl Med J India 13:287–292, 2000
      OpenUrlPubMed
    6. ↵
      UK Prospective Diabetes Study Group: UK Prospective Diabetes Study XII: differences between Asian, Afro-Caribbean and white Caucasian type 2 diabetic patients at diagnosis of diabetes. Diab Medicine 11:670–677, 1994
      OpenUrl
    7. ↵
      Mohan V, Ramachandran A, Snehalatha C, Rema Mohan, Bharani G, Viswanathan M: High prevalence of maturity onset diabetes of the young (MODY) among Indians. Diabetes Care 8:371–374, 1985
      OpenUrlAbstract/FREE Full Text
    8. ↵
      Drake AJ, Smith A, Betts PR, Crowne EC, Shield JPR: Type 2 diabetes in obese white children. Arch Dis Child 86:207–208, 2002
      OpenUrlAbstract/FREE Full Text
    9. ↵
      Ehtisham S, Barrett TG, Shaw NJ: Type 2 diabetes mellitus in UK children-an emerging problem. Diab Medicine 17:867–871, 2000
      OpenUrl
    10. ↵
      Matthews DR, Wallace TM: Children with type 2 diabetes: the risks of complications. Horm Res 57:34–39, 2002
    11. ↵
      Sinha R, Fisch G, Teague B, Tamborlane WC, Banyas B, Allen K, Savoye M, Reiger V, Taksali S, Barbetta G, Sherwin RS, Carpio S: Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 346:802–810, 2002
      OpenUrlCrossRefPubMedWeb of Science
    12. Arslanian S: Type 2 diabetes in children: clinical aspects and risk factors. Horm Res 57:19–28, 2002
      OpenUrl
    13. ↵
      Fagot-Campagna A, Pettitt DJ, Engelgau MM, Burrows NR, Geiss LS, Valdez R, Beckles R, Saaddine J, Gregg EW, Williamson DF, Narayan KM: Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr 136:664–672, 2000
      OpenUrlCrossRefPubMedWeb of Science
    14. ↵
      American Diabetes Association: Type 2 Diabetes in children and adolescents. Pediatrics 105:671–680, 2000
      OpenUrlFREE Full Text
    15. ↵
      Mokdad AH, Serdula MK, Dietz WH, Bowman BA, Marks JS, Koplan JP: The spread of the obesity epidemic in the United States, 1991–1998. JAMA 282:1519–1522, 1999
      OpenUrlCrossRefPubMedWeb of Science
    16. ↵
      Ramachandran A, Vinitha R, Megha Thayyil, Sathish Kumar CK, Sheeba L, Joseph S, Vijay V: Prevalence of overweight in urban Indian adolescent school children. Diabetes Res Clin Prac 57:185–190, 2002
      OpenUrlCrossRefPubMedWeb of Science
    17. ↵
      Swaminathan M: Principles of Nutrition and Dietetics. Appendices. Bangalore, India, Bangalore Printing and Publishing, 1993, p. 495
    18. ↵
      Hagopian WA, Sanjeevi CB, Kockum I, Landin -Olsson M, Karlsen AE, Sundkvist G, Dahlquist G, Palmer J, Lernmark A: Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest 95:1505–1511, 1995
    19. ↵
      Petersen JS, Hejnaes KR, Moody A, Karlsen AE, Marshall MO, Hoier-Madsen M, Boel E, Michelsen BK, Dyrberg T: Detection of GAD65 antibodies in diabetes and other autoimmune disease using a simple radioligand assay. Diabetes 43:459–467, 1994
      OpenUrlAbstract/FREE Full Text
    20. ↵
      Ramachandran A, Snehalatha C, Satyavani K, Sivasankari S, Vijay V: GAD65 antibodies in classification of Asian Indian diabetic subjects with onset between 20 and 40 years. Diabetes Care 22:175–176, 1999
      OpenUrlFREE Full Text
    21. ↵
      Snehalatha C, Ramachandran A, Mohan V, Viswanathan M: Pancreatic beta cell response in insulin treated NIDDM patients limitations of a random C-peptide measurement. Diabete Metab 13:27–30, 1987
      OpenUrlPubMed
    22. ↵
      Madsbad S, Krarup T, McNair P, Christiansen C, Faber OK, Transbol I, Binder C: Practical clinical value of the C-peptide response to glucagon stimulation in the choice of treatment in diabetes mellitus. Acta Med Scand 210:153–156, 1981
      OpenUrlPubMedWeb of Science
    23. ↵
      Kida K: Obesity and type II diabetes in childhood. In Proceedings of Diabetes in Asia, 2002. Colombo, Sri Lanka, Diabetes Association of Sri Lanka, 2002, p. 44
    24. ↵
      Bloomgarden ZT: New insights in obesity. Diabetes Care 25:789–795, 2002
      OpenUrlFREE Full Text
    25. ↵
      Snehalatha C, Ramachandran A: Insulin resistance in Asian Indians (Review Article). Pract Diab Inter 16:19–22, 1999
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    Type 2 Diabetes in Asian-Indian Urban Children
    Ambady Ramachandran, Chamukuttan Snehalatha, Kumpatla Satyavani, Selvaraj Sivasankari, Viswanathan Vijay
    Diabetes Care Apr 2003, 26 (4) 1022-1025; DOI: 10.2337/diacare.26.4.1022

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    Type 2 Diabetes in Asian-Indian Urban Children
    Ambady Ramachandran, Chamukuttan Snehalatha, Kumpatla Satyavani, Selvaraj Sivasankari, Viswanathan Vijay
    Diabetes Care Apr 2003, 26 (4) 1022-1025; DOI: 10.2337/diacare.26.4.1022
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