Decreasing Incidence of Severe Diabetic Microangiopathy in Type 1 Diabetes
Article Figures & Tables
Figures
- Figure 1—
Cumulative incidence of diabetic nephropathy in 600 type 1 diabetic patients with onset of diabetes from 1965 to 1969 (n = 113, group A [○]), 1970 to 1974 (n = 130, group B [•]), 1975 to 1979 (n = 113, group C [□]), and 1979 to 1984 (n = 244, group D [▪]). P < 0.001, log-rank test, pooled over strata. Not all patients in group D have yet been followed for 20 years. For pairwise log-rank test over strata after 20 years of diabetes, see results.
- Figure 2—
Cumulative incidence of proliferative retinopathy in 600 type 1 diabetic patients with onset of diabetes from 1965 to 1969 (n = 113, group A [○]), 1970 to 1974 (n = 130, group B [•]), 1975 to 1979 (n = 113, group C [□]), and 1979 to 1984 (n = 244, group D [▪]). P < 0.001, log-rank test, pooled over strata. Not all patients in group D have yet been followed for 20 years. For pairwise log-rank test over strata after 20 years of diabetes, see results.
Tables
- Table 1—
Patient characteristics and clinical and laboratory data during 20 years of follow-up in 600 patients with type 1 diabetes
Group A (onset from 1965 to 1969) Group B (onset from 1970 to 1974) Group C (onset from 1975 to 1979) Group D (onset from 1979 to 1984) P n 113 130 113 244 — Sex (M/F) 62/51 72/58 65/48 144/100 NS Age at onset of diabetes (years)* 19.8 ± 10.6 20.9 ± 9.8 23.1 ± 8.6 23.2 ± 8.8 0.003 Smoking (%) 69 54 65 45 <0.001 During follow-up HbA1c (%)† 8.9 ± 0.1 8.8 ± 0.1 8.9 ± 0.1 8.5 ± 0.1 0.006 Systolic blood pressure (mmHg)† 138.1 ± 1.2 134.6 ± 1.3 131.9 ± 1.3 127.9 ± 0.8 <0.001 Diastolic blood pressure (mmHg)† 84.7 ± 0.7 82.9 ± 0.7 81.7 ± 0.7 79.2 ± 0.5 <0.001 Mean arterial blood pressure (mmHg)† 102.5 ± 0.8 100.1 ± 0.8 98.4 ± 0.8 95.4 ± 0.6 <0.001 Class of antihypertensive treatment (ACE inhibitor/non-ACE inhibitor) 15/24 29/17 28/6 55/6 <0.001 Time from diabetes onset to start of antihypertensive treatment (years) 16.9 ± 0.4 14.8 ± 0.5 13.9 ± 0.8 13.3 ± 0.6 <0.001
In this Issue
