Urinary Connective Tissue Growth Factor Excretion in Patients With Type 1 Diabetes and Nephropathy

Pathophysiology/Complications

¹Department of Medicine, St. Vincent’s Hospital, University of Melbourne, Fitzroy, Australia
²Fibrogen Inc., San Francisco, California
³Department of Medicine, Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, Australia

Address correspondence and reprint requests to Richard E. Gilbert, University of Melbourne, Department of Medicine, St. Vincent’s Hospital, 41 Victoria Parade, Fitzroy, Victoria, 3065, Australia. E-mail: gilbert{at}medstv.unimelb.edu.au

Diabetes Care 2003 Sep; 26(9): 2632-2636. https://doi.org/10.2337/diacare.26.9.2632

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Figure 1—
A: Correlation between urinary albumin and CTGF-N in patients in with type 1 diabetes and nephropathy. n = 31, R = 0.76, P < 0.001. B: Correlation between TGF-β albumin and CTGF-N. n = 24, R = 0.65, P < 0.001.

Table 1—

Characteristics of study patients

	Normoalbuminuria	Microalbuminuria	Macroalbuminuria no ACEI	Macroalbuminuria with ACEI
n	10	8	5	8
Sex (M:F)	7:3	6:2	4:1	4:4
Age (years)	33 ± 4	39 ± 6	57 ± 8*†	39 ± 4
Duration (years)	14 ± 3	20 ± 7	35 ± 8*	23 ± 3
SBP (mmHg)	130 ± 4	130 ± 7	154 ± 9*†	136 ± 8
DBP (mmHg)	84 ± 2	83 ± 5	83 ± 5	83 ± 6
HbA_1c (%)	8.3 ± 0.6	9.4 ± 0.8	9.1 ± 1.4	9.5 ± 0.7
Se creat (μmol/l)	0.14 ± 0.06	0.09 ± 0.02	0.39 ± 0.13*†‡	0.16 ± 0.02
Creat cl (ml/s)	2.2 ± 0.2	1.8 ± 0.4	0.8 ± 0.4*†‡	1.3 ± 0.3

Data are means ± SE.
*
↵* P < 0.05 vs. normoalbuminuria;
†
↵† P < 0.05 vs. microalbuminuria;
‡
↵‡ P < 0.05 vs. macroalbuminuria with ACE inhibitor treatment. Creat cl, creatinine clearance; DBP, diastolic blood pressure; SBP, systolic blood pressure; Se creat, serum creatinine.

Table 2—

Urinary excretion of albumin, CTGF-N, and TGF-β in patients with type 1 diabetes

	Normoalbuminuria	Microalbuminuria	Macroalbuminuria no ACEI	Macroalbuminuria with ACEI
n	10	8	5	8
Albuminuria (mg/mg)	1.1 ×/÷ 1.1	6.0 ×/÷ 1.4*	177.8 ×/÷ 2.1†	124 ×/÷ 1.1†‡
CTGF-N (ng/mg)	0.23 ×/÷ 1.3	2.1 ×/÷ 1.7*	203 ×/÷ 3.8†	6.5 ×/÷ 1.7‡
TGF-β (ng/mg)	0.77 ×/÷ 0.07	0.61 ×/÷ 0.24	1.09 ×/÷ 0.14†	1.11 ×/÷ 0.11†