Leptin-to-Adiponectin Ratio as a Potential Atherogenic Index in Obese Type 2 Diabetic Patients
- Noriko Satoh, MD, PHD1,
- Mitsuhide Naruse, MD, PHD1,
- Takeshi Usui, MD, PHD1,
- Tetsuya Tagami, MD, PHD1,
- Takayoshi Suganami, MD, PHD2,
- Kazunori Yamada, MD, PHD3,
- Hideshi Kuzuya, MD, PHD3,
- Akira Shimatsu, MD, PHD1 and
- Yoshihiro Ogawa, MD, PHD24
- 1Clinical Research Institute for Endocrine Metabolic Disease, Kyoto Medical Center, Fushimi-ku, Kyoto, Japan
- 2Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, Japan
- 3Diabetes Center, National Hospital Organization, Kyoto Medical Center, Fushimi-ku, Kyoto, Japan
- 4Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstitution of Tooth and Bone, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, Japan
- Address correspondence and reprint requests to Yoshihiro Ogawa, MD, PhD, Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan. E-mail: ogawa.mmm{at}mri.tmd.ac.jp
Article Figures & Tables
Tables
- Table 1—
Baseline characteristics of the study subjects and Spearman’s rank correlation
Variables Nonobese (n = 98) Obese (n = 60) P values Men Women Men Women Men Women n 39 59 30 30 Age (years) 61.7 ± 1.41 60.9 ± 1.04 58.0 ± 2.38 57.7 ± 2.35 NS NS BMI (kg/m2) 22.4 ± 0.27 21.3 ± 0.29 26.6 ± 0.26 27.4 ± 0.35 <0.0001 <0.0001 PWV (cm/s) 1667 ± 40 1700 ± 34 1628 ± 37 1634 ± 42 NS NS Leptin (ng/ml) 3.70 ± 0.25 5.83 ± 0.33 8.90 ± 0.35 11.9 ± 0.59 <0.0001 <0.0001 Adiponectin (mg/ml) 4.84 ± 0.25 8.25 ± 0.28 3.44 ± 0.16 5.09 ± 0.30 0.0003 <0.0001 Leptin/adiponectin 0.85 ± 0.08 0.79 ± 0.06 2.81 ± 0.17 2.59 ± 0.20 <0.0001 <0.0001 Spearman’s rank correlation (P values) Leptin vs. PWV −0.060 (NS) 0.053 (NS) 0.281 (NS) 0.315 (NS) Adiponectin vs. PWV 0.079 (NS) 0.090 (NS) −0.309 (NS) −0.122 (NS) Leptin/adiponectin vs. PWV −0.061 (NS) 0.013 (NS) 0.378 (P = 0.0420) 0.390 (P = 0.0356) -
Data are means ± SE. NS, not significant. Two-tailed Student’s t test was used.
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In this Issue
October 2004, 27(10)
Leptin-to-Adiponectin Ratio as a Potential Atherogenic Index in Obese Type 2 Diabetic Patients
