Elevated C-Reactive Protein Levels Do Not Correspond to Autoimmunity in Type 1 Diabetes
- Andras Treszl, MD,
- Laszlo Szereday, MD,
- Alessandro Doria, MD,
- George L. King, MD and
- Tihamer Orban, MD
- From the Joslin Diabetes Center, Harvard Medical School, Boston Massachusetts
- Address correspondence to Tihamer Orban, MD, Section of Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215. E-mail: torban{at}joslin.harvard.edu
A large body of data now supports that high normal or elevated C-reactive protein (CRP) levels are a marker of ongoing low-grade chronic inflammatory process and may predict a higher risk for cardiovascular disease. Type 1 diabetes is a T-cell-mediated disease (1), and autoantibodies (2) are considered to be the surrogate markers for the autoimmune process and have been used for disease prediction (3). However, little is known about the relationship between diabetes autoimmunity and the acute-phase response. We studied the relationship of islet cell autoimmunity …
In this Issue
November 2004, 27(11)
Elevated C-Reactive Protein Levels Do Not Correspond to Autoimmunity in Type 1 Diabetes
