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Letters: Comments and Responses

Benefits and Risks of Solitary Islet Transplantation for Type 1 Diabetes Using Steroid-Sparing Immunosuppression

Response to Hirshberg et al.

  1. M. Arthur Charles, MD, PHD, and
  2. Jean-Louis Selam, MD
  1. From the Diabetes Research Center
  1. Address correspondence to Dr. M. Arthur Charles, Diabetes Research Center, 2492 Walnut Ave., Suite 130, Tustin, CA 92780. E-mail: macharle{at}uci.edu
Diabetes Care 2004 May; 27(5): 1249-1250. https://doi.org/10.2337/diacare.27.5.1249-a
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Response to Hirshberg et al.

The report by Hirshberg et al. (1) describes the National Institutes of Health (NIH) experience in islet-only transplantation using the medical indication of severe hypoglycemia. Although the report details islet transplantation, there was little hypoglycemic information. Because of the potential side effects comparing the medical indication and the treatment, we have scientific, educational, and ethical concerns.

The first concern is the relative morbidity and mortality between severe hypoglycemia and islet transplantation. The mortality associated with severe hypoglycemia is unclear, but estimates show that 0–4% of type 1 diabetic patients die of hypoglycemia (2–4). Is there a mortality estimate with the immunosuppression regimen plus transplantation? Regarding morbidity, hypoglycemic rates appear significant in the Diabetes Control and Complications Trial (DCCT), but these events generated a hospitalization rate of only 1.1 per 100 patient years (4). At least 2 of 6 patients in the transplant group had life-threatening side effects and a hospitalization rate of over 22 per 100 patient- years.

It would be appropriate to define and quantitate hypoglycemic events before and after transplantation. Hypoglycemic complications, e.g., accidents, emergency room visits, and all-cause hospitalizations before and after transplantation should be compared. It was unclear whether islet transplantation or changes in exogenous insulin regimens reduced the rates of severe hypoglycemic events.

There was no description of the methods and personnel involved in the management of severe hypoglycemia before transplantation. Successful educational methods are reported; were educational methods used? Were patients treated with the most effective regimens currently available, e.g., ultralente twice a day, glargine insulin, and rapid-acting insulin analogs? It should be clear that NPH and regular insulins were not being used before transplantation. Was continuous subcutaneous insulin infusion (CSII) used, and were CSII basal rate–only methods used? For future studies, the use of glucose sensor devices may also appear useful. Since continuous intraperitoneal insulin infusion (CIPII) has been described to markedly reduce severe hypoglycemic events, were the patients offered compassionate use of CIPII? All of the above treatments, when used by experienced clinicians, appear considerably safer than the procedures described for islet transplantation.

Regarding ethics, did consent forms advise patients of the above successful severe hypoglycemia treatments?

Since additional U.S. sites will use islet transplantation for treatment of severe hypoglycemia, such teams must include collaborators with expertise regarding severe hypoglycemia. In future islet transplantation studies, the transplantation teams may wish to standardize not only a definition of severe hypoglycemia, but also diagnostic and treatment protocol algorithms before islet transplantation. The NIH would seem the obvious site to initiate such protocols.

Footnotes

  • M.A.C. has received honoraria for speaking engagements from Aventis Pharmaceuticals, and Aventis provides funds to the research center in order to conduct studies on glargine insulin.

  • DIABETES CARE

References

  1. ↵
    Hirshberg B, Rother KI, Digon BJ 3rd, Lee J, Gaglia JL, Hines K, Read EJ, Chang R, Wood BJ, Harlan DM: Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression. Diabetes Care 24:3288–3295, 2003
    OpenUrl
  2. ↵
    Portuese F, Orchard T: Mortality in insulin-dependent diabetes. In Diabetes in America. Washington, DC, U.S. Govt. Printing Office, 1995, p. 221–232 (NIH publ. no. 95-1468:221-232)
  3. Cryer PE: Hypoglycemia in Diabetes. Diabetes Care 52:2083–2089, 2003
    OpenUrl
  4. ↵
    The DCCT Research Group: Adverse events and their association with treatment regimens in the DCCT. Diabetes Care 18:1415–1427, 1995
    OpenUrlAbstract/FREE Full Text
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Diabetes Care: 27 (5)

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Benefits and Risks of Solitary Islet Transplantation for Type 1 Diabetes Using Steroid-Sparing Immunosuppression
M. Arthur Charles, Jean-Louis Selam
Diabetes Care May 2004, 27 (5) 1249-1250; DOI: 10.2337/diacare.27.5.1249-a

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Benefits and Risks of Solitary Islet Transplantation for Type 1 Diabetes Using Steroid-Sparing Immunosuppression
M. Arthur Charles, Jean-Louis Selam
Diabetes Care May 2004, 27 (5) 1249-1250; DOI: 10.2337/diacare.27.5.1249-a
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  • Primary Aldosteronism in Diabetic Subjects With Resistant Hypertension
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