Skip to main content
  • More from ADA
    • Diabetes
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care
  • Subscribe
  • Log in
  • My Cart
  • Follow ada on Twitter
  • RSS
  • Visit ada on Facebook
Diabetes Care

Advanced Search

Main menu

  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • Special Article Collections
    • ADA Standards of Medical Care
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • Special Article Collections
    • ADA Standards of Medical Care
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Individual Subscriptions
    • Institutional Subscriptions and Site Licenses
    • Access Institutional Usage Reports
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Special Podcast Series: Therapeutic Inertia
    • Special Podcast Series: Influenza Podcasts
    • Special Podcast Series: SGLT2 Inhibitors
    • Special Podcast Series: COVID-19
  • Submit
    • Submit a Manuscript
    • Journal Policies
    • Instructions for Authors
    • ADA Peer Review
  • More from ADA
    • Diabetes
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care

User menu

  • Subscribe
  • Log in
  • My Cart

Search

  • Advanced search
Diabetes Care
  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • Special Article Collections
    • ADA Standards of Medical Care
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • Special Article Collections
    • ADA Standards of Medical Care
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Individual Subscriptions
    • Institutional Subscriptions and Site Licenses
    • Access Institutional Usage Reports
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Special Podcast Series: Therapeutic Inertia
    • Special Podcast Series: Influenza Podcasts
    • Special Podcast Series: SGLT2 Inhibitors
    • Special Podcast Series: COVID-19
  • Submit
    • Submit a Manuscript
    • Journal Policies
    • Instructions for Authors
    • ADA Peer Review
Letters: Comments and Responses

Adiponectin in Youth

Response to Stefan et al.

  1. Fida Bacha, MD,
  2. Rola Saad, MD,
  3. Neslihan Gungor, MD and
  4. Silva A. Arslanian, MD
  1. From the Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania
  1. Address correspondence to Silva A. Arslanian, MD, Division of Endocrinology, Children’s Hospital of Pittsburgh, 3705 Fifth Ave. at DeSoto Street, Pittsburgh, PA 15213. E-mail: silva.arslanian{at}chp.edu
Diabetes Care 2004 Jun; 27(6): 1520-1521. https://doi.org/10.2337/diacare.27.6.1520
PreviousNext
  • Article
  • Info & Metrics
  • PDF
Loading

Response to Stefan et al.

We appreciate the comments of Stefan et al. (1) in this issue of Diabetes Care regarding adiponectin in youth. We are excited to have received the opinion of investigators in internal medicine, since traditionally pediatric investigations seldom cross the boundaries to adult medicine. The changing face of childhood diabetes might be playing a role (2). We offer the following responses.

1) Our study demonstrated associations and correlations between adiponectin and proinsulin and the proinsulin-to-insulin ratio. We never implied that a direct effect of adiponectin on insulin secretory function exists. However, as recommended by Stefan et al., we investigated the relationship between the proinsulin-to-insulin ratio and adiponectin after adjusting for insulin sensitivity per metabolically active fat-free mass. The partial correlation coefficient of adiponectin to the proinsulin-to-insulin ratio after controlling for insulin sensitivity was r = −0.24, two-tailed P = 0.12, and one-tailed P = 0.06. Furthermore, in a multiple regression analysis with proinsulin-to-insulin ratio as the dependent variable and adiponectin and insulin sensitivity as the independent variables, adiponectin (P = 0.007) and not insulin sensitivity (P = 0.60) was the significant independent correlate of the proinsulin-to-insulin ratio (R2 = 0.168, P = 0.02 with adiponectin and insulin sensitivity in the formula; R2 = 0.162, P = 0.007 with only adiponectin in the formula). Also, in an effort to determine if adiponectin is related to an index of glucose homeostasis, we evaluated the correlation of adiponectin with the glucose disposition index (product of insulin sensitivity × first-phase insulin secretion), which revealed that r = 0.35 and P = 0.013.

2) The observation by Roder et al. (3) that the association between the proinsulin-to-insulin ratio and acute insulin response was only present in diabetic adults and not in nondiabetic subjects is contrary to our findings in healthy adolescents. Extrapolating observations from 60-year-old subjects to adolescents may not be justified, especially taking into consideration the uniqueness of puberty-related changes in insulin sensitivity and secretion (2,4). Analysis of our unpublished data demonstrates that first-phase insulin secretion during a hyperglycemic clamp correlates positively with proinsulin (r = 0.43, P = 0.04) and the proinsulin-to-insulin ratio (r = 0.50, P = 0.01) in normal-weight adolescents (n = 23) with no correlations in obese adolescents (n = 26). Thus, in normal adolescents, the puberty-related increase in insulin secretion may also be accompanied by increased proinsulin secretion, whereas in obese adolescents, this relationship may disappear due to variable degrees of β-cell compensation.

In summary, despite the wealth of data in adults with respect to insulin sensitivity and secretion, gradually accumulating data in pediatrics would suggest that developmental differences in these parameters are distinguishing features of youth. At the moment, our data in pediatrics remain supportive of an important relationship between adiponectin and measures of β-cell function.

Acknowledgments

This work was supported by U.S. Public Health Service Grants Ro1 HD27503, K24 HD01357, and MO1-RR00084, the General Clinical Research Center, and Eli-Lilly.

Footnotes

  • DIABETES CARE

References

  1. ↵
    Stefan N, Stumvoll M, Häring H, Fritsche A: Adiponectin in youth (Letter). Diabetes Care 27:1519–1520, 2004
    OpenUrlFREE Full Text
  2. ↵
    Arslanian SA: Insulin resistance and insulin secretion in childhood and adolescence: their role in type 2 diabetes in youth. In Type 2 Diabetes in Childhood and Adolescence. Silink M, Kida K, Rosenbloom A, Eds. London, Martin Dunitz Publishing, 2003, p. 93–116
  3. ↵
    Roder MF, Schwartz RS, Prigeon RL, Kahn SF: Reduced pancreatic B cell compensation to the insulin resistance of aging: impact on proinsulin and insulin levels. J Clin Endocrinol Metab 85:2275–2280, 2000
    OpenUrlCrossRefPubMedWeb of Science
  4. ↵
    Arslanian SA, Kalhan SC: Correlations between fatty acid and glucose metabolism: potential explanation of insulin resistance of puberty. Diabetes 43:908–914, 1994
    OpenUrlAbstract/FREE Full Text
PreviousNext
Back to top
Diabetes Care: 27 (6)

In this Issue

June 2004, 27(6)
  • Table of Contents
  • About the Cover
  • Index by Author
Sign up to receive current issue alerts
View Selected Citations (0)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about Diabetes Care.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Adiponectin in Youth
(Your Name) has forwarded a page to you from Diabetes Care
(Your Name) thought you would like to see this page from the Diabetes Care web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Adiponectin in Youth
Fida Bacha, Rola Saad, Neslihan Gungor, Silva A. Arslanian
Diabetes Care Jun 2004, 27 (6) 1520-1521; DOI: 10.2337/diacare.27.6.1520

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Add to Selected Citations
Share

Adiponectin in Youth
Fida Bacha, Rola Saad, Neslihan Gungor, Silva A. Arslanian
Diabetes Care Jun 2004, 27 (6) 1520-1521; DOI: 10.2337/diacare.27.6.1520
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Acknowledgments
    • Footnotes
    • References
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Primary Aldosteronism in Diabetic Subjects With Resistant Hypertension
  • Primary Aldosteronism in Diabetic Subjects With Resistant Hypertension
  • Flexible Intensive Insulin Therapy in Adults With Type 1 Diabetes and High Risk for Severe Hypoglycemia and Diabetic Ketoacidosis
Show more Letters: Comments and Responses

Similar Articles

Navigate

  • Current Issue
  • Standards of Care Guidelines
  • Online Ahead of Print
  • Archives
  • Submit
  • Subscribe
  • Email Alerts
  • RSS Feeds

More Information

  • About the Journal
  • Instructions for Authors
  • Journal Policies
  • Reprints and Permissions
  • Advertising
  • Privacy Policy: ADA Journals
  • Copyright Notice/Public Access Policy
  • Contact Us

Other ADA Resources

  • Diabetes
  • Clinical Diabetes
  • Diabetes Spectrum
  • Scientific Sessions Abstracts
  • Standards of Medical Care in Diabetes
  • BMJ Open - Diabetes Research & Care
  • Professional Books
  • Diabetes Forecast

 

  • DiabetesJournals.org
  • Diabetes Core Update
  • ADA's DiabetesPro
  • ADA Member Directory
  • Diabetes.org

© 2021 by the American Diabetes Association. Diabetes Care Print ISSN: 0149-5992, Online ISSN: 1935-5548.