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Clinical Care/Education/Nutrition

A Randomized, Prospective Trial Comparing the Efficacy of Continuous Subcutaneous Insulin Infusion With Multiple Daily Injections Using Insulin Glargine

  1. Elizabeth A. Doyle (Boland), MSN APRN, CDE,
  2. Stuart A. Weinzimer, MD,
  3. Amy T. Steffen, BS,
  4. Jo Ann H. Ahern, MSN APRN, CDE,
  5. Miranda Vincent, MSN APRN, CDE and
  6. William V. Tamborlane, MD
  1. From the Department of Pediatrics and the Children’s Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut
  1. Address correspondence and reprint requests to Elizabeth Doyle, MSN APRN, CDE, Yale Diabetes Research Program, 2 Church St. South, Suite 312, New Haven, CT 06519. E-mail: elizabeth.doyle{at}yale.edu
Diabetes Care 2004 Jul; 27(7): 1554-1558. https://doi.org/10.2337/diacare.27.7.1554
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  • Figure 1—
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    Figure 1—

    HbA1c levels in the two treatment groups. The difference between CSII (⧫) and glargine (▪) at baseline is not significant. At 16 weeks, HbA1c levels in the CSII group were significantly lower than base-line (P < 0.02) and versus glargine (P < 0.05).

  • Figure 2—
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    Figure 2—

    Mean fingerstick blood glucose levels for each meal. The difference between CSII (□) and glargine (▪) at breakfast is nonsignificant. The differences between CSII and glargine at all other time points are significant (P < 0.001)

Tables

  • Figures
  • Table 1—

    Baseline clinical characteristics of the two treatment groups

    CSIIMDIP
    n1616—
    Age (years)12.5 ± 3.213 ± 2.80.637
    Sex (F/M)10/68/80.722
    Race (white/Hispanic/black)11/3/213/2/10.705
    Duration of diabetes (years)6.8 ± 3.85.6 ± 4.00.391
    Initial treatment (no. of injections)12 b.i.d./4 MDI14 b.i.d./2 MDI0.654
    TDD prestudy enrollment (units/kg)1.4 ± 0.51.1 ± 0.30.087
    • Data are means ± SD.

  • Table 2—

    Basal/bolus doses at 16 weeks in the two treatment groups

    CSIIMDIP
    n1616—
    TDD (units/kg)0.9 ± 0.21.2 ± 0.20.003
    Daily basal dose (units/kg)0.6 ± 0.10.7 ± 0.10.137
    Carbohydrate-to-insulin ratio (no. of grams per 1 unit insulin)14 ± 710 ± 30.071
    No. daily basal rates5.4 ± 1.0——
    Mean day (7:00 a.m. to 9:00 p.m.) rate1.6 ± 0.8——
    Mean night (10:00 p.m. to 6:00 a.m.) rate1.4 ± 0.7——
    • Data are means ± SD.

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Diabetes Care: 27 (7)

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July 2004, 27(7)
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A Randomized, Prospective Trial Comparing the Efficacy of Continuous Subcutaneous Insulin Infusion With Multiple Daily Injections Using Insulin Glargine
Elizabeth A. Doyle (Boland), Stuart A. Weinzimer, Amy T. Steffen, Jo Ann H. Ahern, Miranda Vincent, William V. Tamborlane
Diabetes Care Jul 2004, 27 (7) 1554-1558; DOI: 10.2337/diacare.27.7.1554

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A Randomized, Prospective Trial Comparing the Efficacy of Continuous Subcutaneous Insulin Infusion With Multiple Daily Injections Using Insulin Glargine
Elizabeth A. Doyle (Boland), Stuart A. Weinzimer, Amy T. Steffen, Jo Ann H. Ahern, Miranda Vincent, William V. Tamborlane
Diabetes Care Jul 2004, 27 (7) 1554-1558; DOI: 10.2337/diacare.27.7.1554
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