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Clinical Care/Education/Nutrition

Caffeine Ingestion Is Associated With Reductions in Glucose Uptake Independent of Obesity and Type 2 Diabetes Before and After Exercise Training

  1. SoJung Lee, PHD1,
  2. Robert Hudson, MD, PHD2,
  3. Katherine Kilpatrick, MD3,
  4. Terry E. Graham, PHD4 and
  5. Robert Ross, PHD12
  1. 1School of Physical and Health Education, Queen’s University, Kingston, Ontario, Canada
  2. 2Department of Medicine, Division of Endocrinology and Metabolism, Queen’s University, Kingston, Ontario, Canada
  3. 3Department of Medicine, Division of Geriatrics, Queen’s University, Kingston, Ontario, Canada
  4. 4Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
  1. Address correspondence and reprint requests to Robert Ross, PhD, School of Physical and Health Education, Queen’s University, Kingston, Ontario, Canada, K7L 3N6. E-mail: rossr{at}post.queensu.ca
Diabetes Care 2005 Mar; 28(3): 566-572. https://doi.org/10.2337/diacare.28.3.566
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Abstract

OBJECTIVE—We investigated the effect of caffeine ingestion on insulin sensitivity in sedentary lean men (n = 8) and obese men with (n = 7) and without (n = 8) type 2 diabetes. We also examined whether chronic exercise influences the relationship between caffeine and insulin sensitivity in these individuals.

RESEARCH DESIGN AND METHODS—Subjects underwent two hyperinsulinemic-euglycemic clamp procedures, caffeine (5 mg/kg body wt) and placebo, in a double-blind, randomized manner before and after a 3-month aerobic exercise program. Body composition was measured by magnetic resonance imaging.

RESULTS—At baseline, caffeine ingestion was associated with a significant reduction (P < 0.05) in insulin sensitivity by a similar magnitude in the lean (33%), obese (33%), and type 2 diabetic (37%) groups in comparison with placebo. After exercise training, caffeine ingestion was still associated with a reduction (P < 0.05) in insulin sensitivity by a similar magnitude in the lean (23%), obese (26%), and type 2 diabetic (36%) groups in comparison with placebo. Exercise was not associated with a significant increase in insulin sensitivity in either the caffeine or placebo trials, independent of group (P > 0.10).

CONCLUSIONS—Caffeine consumption is associated with a substantial reduction in insulin-mediated glucose uptake independent of obesity, type 2 diabetes, and chronic exercise.

  • FFA, free fatty acid

Footnotes

  • A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    • Accepted December 6, 2004.
    • Received October 8, 2004.
  • DIABETES CARE
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Diabetes Care: 28 (3)

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March 2005, 28(3)
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Caffeine Ingestion Is Associated With Reductions in Glucose Uptake Independent of Obesity and Type 2 Diabetes Before and After Exercise Training
SoJung Lee, Robert Hudson, Katherine Kilpatrick, Terry E. Graham, Robert Ross
Diabetes Care Mar 2005, 28 (3) 566-572; DOI: 10.2337/diacare.28.3.566

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Caffeine Ingestion Is Associated With Reductions in Glucose Uptake Independent of Obesity and Type 2 Diabetes Before and After Exercise Training
SoJung Lee, Robert Hudson, Katherine Kilpatrick, Terry E. Graham, Robert Ross
Diabetes Care Mar 2005, 28 (3) 566-572; DOI: 10.2337/diacare.28.3.566
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