SDF-1 Genotype Influences Insulin-Dependent Mobilization of Adult Progenitor Cells in Type 2 Diabetes
- Per M. Humpert, MD,
- Renate Neuwirth,
- Marco J. Battista,
- Olga Voronko, MD,
- Maximilian von Eynatten, MD,
- Ilze Konrade, MD,
- Gottfried Rudofsky, Jr, MD,
- Thoralf Wendt, MD,
- Andreas Hamann, MD,
- Michael Morcos, MD,
- Peter P. Nawroth, MD and
- Angelika Bierhaus, PHD
- Address correspondence and reprint requests to Dr. Angelika Bierhaus, PHD, Medizinische Klinik 1, University of Heidelberg, INF 410, 69120 Heidelberg, Germany. E-mail: angelika.bierhaus{at}med.uni-heidelberg.de
Article Figures & Tables
Figures
- Figure 1—
A: FACS analysis. Double staining of CD34 and CD133 antigens on pBMCs. Fluorescein isothiocyanate (FITC)- and phycoerythrin (PE)-coupled isotype controls were used for normalization. CD34+/133+ adult PCs are shown in the upper right quadrant. B: Number of PCs (% of pBMCs) in patients with poorly controlled type 2 diabetes before (gray bar) and after 5.4 weeks of insulin therapy (n = 11, black bar). (P value as given by paired t test for normally distributed values.) C: Correlation of CD34+/133+ in pBMCs (%) with fasting blood glucose (mmol/l). (R, Pearson’s correlation coefficient; P value as given for Pearson’s correlation.) D: Mobilization of CD34+/133+ cells in pBMCs (%) after 5.4 weeks of treatment with additional insulin for carriers of SDF1-3′G/G allele (gray bar) and carriers of SDF1-3′A/G allele (black bar). P value as given by Student’s t test.
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