The Effect of Rosiglitazone on Overweight Subjects With Type 1 Diabetes

Clinical Care/Education/Nutrition

From the University of Texas Southwestern Medical Center at Dallas, Dallas, Texas

Address correspondence and reprint requests to Suzanne M. Strowig, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-8858. E-mail: suzanne.strowig{at}utsouthwestern.edu

Diabetes Care 2005 Jul; 28(7): 1562-1567. https://doi.org/10.2337/diacare.28.7.1562

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Figure 1—
Change in mean A1C level (A) and total daily insulin dose (B) based on baseline BMI in type 1 diabetic subjects after 8 months of treatment with insulin and rosiglitazone or insulin and placebo. *P < 0.05 vs. rosiglitazone-treated subjects with a BMI <30 kg/m²; †P < 0.05 vs. rosiglitazone-treated subjects with a BMI ≥30 kg/m².

Table 1—

Baseline characteristics

	Rosiglitazone + insulin	Placebo + insulin
n	25	25
Age (years)	43.7 ± 13.3	41.1 ± 9.2
Sex (M/F)	16/9	18/7
Ethnic group (n)	22 Caucasian, 3 African American	23 Caucasian, 1 African American, 1 Hispanic
Duration of diabetes (years)	20.7 ± 13.3	18.1 ± 9.3
Waist-to-hip ratio	0.91 ± 0.07	0.93 ± 0.06
Fasting C-peptide (ng/ml)	0.3 ± 0.3	0.3 ± 0.3

Table 2—

Results before and 32 weeks after treatment with rosiglitazone and insulin or placebo and insulin

	Rosiglitazone and insulin			Placebo and insulin
		Baseline	Week 32	Baseline	Week 32
Weight (kg)	97.2 ± 11.8	100.6 ± 16.0*	96.4 ± 12.2	99.1 ± 15.0*
BMI (kg/m²)	32.7 ± 5.4	34.0 ± 7.4*	31.1 ± 3.1	32.0 ± 4.2*
Systolic blood pressure (mmHg)	137.4 ± 15.6†	128.8 ± 14.8*	125.8 ± 10.0	127.5 ± 14.0
Diastolic blood pressure (mmHg)	87.2 ± 9.4	79.4 ± 7.2‡	84.7 ± 7.0	83.2 ± 7.1
Insulin dose (units/day)	77.5 ± 28.6	75.3 ± 33.1	74.0 ± 33.8	82.0 ± 48.9*
Fasting plasma glucose (mg/dl)	172.6 ± 68.3	153.3 ± 66.4	185.8 ± 90.6	173.4 ± 64.8
A1C (%)	7.9 ± 1.3	6.9 ± 0.7‡	7.7 ± 0.8	7.0 ± 0.9‡
Total cholesterol (mg/dl)	201.9 ± 37.6†	195.2 ± 37.5§	177.9 ± 33.1	175.1 ± 31.7
LDL cholesterol (mg/dl)	117.8 ± 32.0	120.1 ± 35.0	103.4 ± 25.2	102.6 ± 25.4
HDL cholesterol (mg/dl)	53.9 ± 20.5	53.6 ± 19.4	47.8 ± 15.0	49.1 ± 15.8
VLDL cholesterol (mg/dl)	15.8 ± 13.2	16.4 ± 9.8	13.8 ± 9.4	14.6 ± 15.6
Triglycerides (mg/dl)	108.1 ± 64.6	101.8 ± 53.8	92.8 ± 38.9	85.4 ± 39.7
VLDL triglycerides (mg/dl)	66.8 ± 57.6	61.9 ± 46.6	55.8 ± 31.6	48.8 ± 33.0
Hemoglobin (gm/dl)	14.4 ± 1.5	13.6 ± 1.9‡§	14.5 ± 1.0	14.5 ± 1.0
Hematocrit (%)	42.0 ± 3.9	39.8 ± 5.1‡§	42.3 ± 3.0	42.2 ± 2.9