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Pathophysiology/Complications

Osteoprotegerin Is Associated With Silent Coronary Artery Disease in High-Risk but Asymptomatic Type 2 Diabetic Patients

  1. Antoine Avignon, MD1,
  2. Ariane Sultan, MD1,
  3. Christophe Piot, MD2,
  4. Stéphane Elaerts, MB3,
  5. Jean Paul Cristol, MD3 and
  6. Anne Marie Dupuy, MD3
  1. 1Metabolic Disease Department, Lapeyronie Hospital, Montpellier, France
  2. 2Cardiology B Department, Arnaud de Villeneuve Hospital, Montpellier, France
  3. 3Biochemistry Department, Lapeyronie Hospital, Montpellier, France
  1. Address correspondence and reprint requests to Antoine Avignon, Metabolic Disease Department, Lapeyronie Hospital, 371, Av. Doyen G. Giraud, 34295, Montpellier, Cedex 5, France. E-mail: a-avignon{at}chu-montpellier.fr
Diabetes Care 2005 Sep; 28(9): 2176-2180. https://doi.org/10.2337/diacare.28.9.2176
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Tables

  • Table 1—

    Characteristics of the CAD and NO-CAD groups

    CADNO-CADP
    n2020
    Sex (men/women)15/515/51.000
    Age (years)59.8 ± 9.560.9 ± 9.60.723
    Duration of diabetes (years)12.0 ± 6.610.5 ± 5.90.444
    BMI (kg/m2)29.8 ± 4.529.0 ± 3.60.543
    A1C (%)8.9 ± 2.78.3 ± 2.00.434
    Left ventricular ejection fraction56 ± 861 ± 90.059
    Total cholesterol (mg/dl)211 ± 39198 ± 380.281
    LDL cholesterol (mg/dl)131 ± 37104 ± 410.033
    HDL cholesterol (mg/dl)45 ± 858 ± 170.005
    Triglycerides (mg/dl)145 (59–395)142 (72–390)
    Subjects with triglycerides >150 mg/dl (%)45.050.00.752
    Nephropathy (%)50.05.00.001
    Retinopathy (%)40.025.00.311
    PAD (%)20.00.00.035
    Smokers (%)35.020.00.288
    Family history of CAD (%)5.00.00.311
    Hypertension (%)95.085.00.282
    Lp(a) (mg/dl)13 (10–165)21 (10–95)
    Subjects with Lp(a) levels >30 mg/dl (%)30.0400.507
    hs-CRP (mg/l)3.30 (0.37–28.24)1.92 (0.06–13.40)
    Subjects with hs-CRP levels >median value (%)60.035.00.113
    Adiponectin (μg/ml)7.17 (1.13–33.34)11.55 (3.72–46.55)
    Subjects with adiponectin levels <median value (%)60.040.00.206
    OPG (pmol/l)13.97 (1.31–20.04)9.44 (0.10–25.88)
    Subjects with OPG levels >median value (%)70.025.00.004
    • Data are means ± SD or median (range) unless otherwise indicated.

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Diabetes Care: 28 (9)

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September 2005, 28(9)
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Osteoprotegerin Is Associated With Silent Coronary Artery Disease in High-Risk but Asymptomatic Type 2 Diabetic Patients
Antoine Avignon, Ariane Sultan, Christophe Piot, Stéphane Elaerts, Jean Paul Cristol, Anne Marie Dupuy
Diabetes Care Sep 2005, 28 (9) 2176-2180; DOI: 10.2337/diacare.28.9.2176

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Osteoprotegerin Is Associated With Silent Coronary Artery Disease in High-Risk but Asymptomatic Type 2 Diabetic Patients
Antoine Avignon, Ariane Sultan, Christophe Piot, Stéphane Elaerts, Jean Paul Cristol, Anne Marie Dupuy
Diabetes Care Sep 2005, 28 (9) 2176-2180; DOI: 10.2337/diacare.28.9.2176
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